牛痘疫苗致炎兔皮提取物治疗老年带状疱疹后遗神经痛及对血清IL-6的影响.pdfVIP

2007；27(12) 南方医科大学学报(J South Med Univ) ·1941． 牛痘疫苗致炎兔皮提取物治疗老年带状疱疹后遗神经痛及对血清IL．6的 影响 杨晓梅 ，何荣国 (’白云区石井人民医院皮肤科，广东 广州 510430；2广州市第十二人民医院皮肤科，广东 广 州 5106201 摘要：目的 探讨牛痘疫苗致炎兔皮提取物治疗老年带状疱疹后遗神经痛f PUN)的临床效果及其对患者血清IL．6的 影响。方法 老年PHN44例，随机分为2组．2组均在常规抗病毒的基础上，A组加用牛痘疫苗致炎兔皮提取物注射液． B组加用口服消炎痛(吲哚美辛)片，疗程14d，以vAS评分法评价治疗前后的疼痛强度变化；检测治疗前和治疗后外周 血清IL．6水平变化。结果 A组治疗前后VAS评分显著下降(P0．叭)，B组治疗前后VAS评分降低不明显(P0．05)。 A、B两组患者治疗前血清IL-6较正常对照组显著性增高：A组治疗后血清IL-6显著性降低(P0．001)；B组治疗前后血 清IL．6降低不明显(P0．05)。结论 牛痘疫苗致炎兔皮提取物对缓解PHN患者的神经病理性疼痛作用快，效果显著，并 能明显降低血清IL．6浓度。 关键词：老年人；带状疱疹后遗神经痛；牛痘疫苗致炎兔皮提取物；白细胞介素．6 中图分类号：R758．63 文献标识码：A 文章编号：1673-4254(2007)12．1941．03 Effect of extracts from rabbit skin inflamed by vaccinia virus in the management of postherpetic neuralgia and on serum interleukin一6 level in aged patients YANG Xiao-mei’，HE Rong-guo ’Department ofDermatology，Shijing People’S Hospital ofBaiyun District，Guangzhou 5 10430，China~~)epartment ofDermatology， Guangzhou No．12 People’S Hospital，Guangzhou 510620，China Abstract Objective To observe the effect of the extracts from rabbit skin inflamed by vaccinia virus for injection， a commercially available agent(Analgecine)，in the treatment ofpostherpetic neuralgia(PHN)in aged patients and its influence on serum interleukin-6(IL-6)leve1．Methods A total of44 elderly patients with PHN were randomly divided into two groups． In addition to the conventional antiviral therapy，patients in group A were given analgecine， and those in group B given indomethacin tablet．After the completion ofthe 14-day treatment course，the therapeutic effects were evaluated using visual analogue scale(VAS)， and the changes in serum IL-6 levels after treatment were measured． Results 111e SCOre of VAS decreased significantly after treatment in group A(PO．O1)，but not in group B(尸O．05)．In both groups，the serumⅡ，6 level before treatment Was significan