Mass Spectrometry, GC-MS and LC-MS - 质谱与微量分析实验室.PDF

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Mass Spectrometry, GC-MS and LC-MS - 质谱与微量分析实验室.PDF

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Mass Spectrometry, GC-MS and LC-MS - 质谱与微量分析实验室

Analytical Chemistry (2015) Chapter 21 – Mass Spectrometry, GC-MS and LC-MS Wang-Hsien Ding Ext: 65905 Office: S1-513 E-mail: wanghsiending@ 1 What is mass spectrometry?  An analytical tool measuring molecular weight (MW) of sample  Only picomolar(10-12 M) concentrations required  Within an accuracy of 0.01% of total weight of sample (for a MW of 40 kDa, there is only a 4 Da error) and within 5 ppm (0.0005%) for small organic molecules  Ability of analyzing small and large molecules  It can detect structural modifications  Isotopic ratio of atoms in samples 2 1 MS Applications Biotechnology: analysis of proteins, peptides, oligonucleotides Pharmaceutical: pharmokinetics, drugs discovery, combinatorial chemistry, drug metabolism Clinical: neonatal screening, haemoglobin analysis, drug testing Environmental: water, food, air quality (PCBs, Dioxins) Geological: oil composition 3 The Components of Mass Spectrometer Mass Ion Ion source analyzer detector Vacuum pump Sample inlet 4 2 5