DNA编码分子库Nature HitGen--Unlocking the power of DNA-encoded libraries.pdfVIP

ADVERTISEMENT FEATURE HitGen Ltd. Unlocking the power of DNA-encoded libraries HitGen’s advanced encoded library technology, including its recently released nonexclusive-use OpenDEL and macrocycle libraries, affords exciting opportunities for those involved in early-stage drug discovery around challenging targets. aking and screening DNA-encoded a through intramolecular hydrogen bonds. As a libraries (DELs), in which small-mole- result, macrocycles are increasingly proving to Mcule compounds are attached to DNA be effective ligands for proteins previously con- tags, is an innovative way of rapidly generating sidered undruggable. high-quality leads for difficult biological targets. In keeping with its library-design principles, By designing and making hundreds of chemically HitGen has focused on the use of multiple scaf- diverse scaffolds, each of which provides a basis folds to generate a highly diverse DEL of more for the generation of a large and highly diverse than 50 million macrocycles based on over 100 library of drug-like molecules, HitGen has estab- different ring scaffolds. What sets this library lished a versatile platform for early-stage drug apart is its wide range of macrocyclic classes, b discovery that is already producing exciting hits inc