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连续性血液净化在哮喘治疗中的应用天津市第三中心医院 ICU，天津，300170【摘要】目的 研究连续性血液净化治疗对改变肺机械参数细胞因子水平血气分析的。确定应用碳酸氢盐置换液与乳酸盐置换液在CBP治疗中的差别。方法 对照组A、碳酸氢盐组B和乳酸盐组C结果BC组肺机械参数，细胞因子水平下降pH值及氧分压得到改善（是上升还是下降，写明白）对比碳酸氢盐置换液组和乳酸盐置换液组，对血清电解质水平、PaO2）、动脉血乳酸无明显影响。（主语是谁）乳酸盐PaCO2）明显低于碳酸氢盐。结论 联合应用CBP可以更快改善肺机械参数，迅速降低细胞因子水平，同时改善机体血气分析（改善。。。分析，搭配不当）乳酸盐置换液更好改善二氧化碳潴留。 【关键词】连续性血液净化CBP；；肺机械参数；细胞因子；血气分析；乳酸；电解质The study of continuous blood purification in Severe asthma XU lei，LI zhi-bo，GAO xin-jing，LI jun，ZHANG jie，ICU department，Tianjin Third Central Hospital，Tianjin，300170，China 【Abstract】Objective To study the mechanism of Continuous blood purification（CBP） improve the lung Mechanical Ventilation parameter、cytokine level and blood gas analysis in severe asthma treatment. determine the difference of the bicarbonate displacement liquid and lactate displacement liquid. Methods twenty six severe asthma patients are divided into control group（10）、bicarbonate group（8）and lactate group（8）. Allow the treatment 24 hours of Mechanical Ventilation（control group）、Mechanical Ventilation+CBP（bicarbonate group）and Mechanical Ventilation+CBP（lactate group）.Comparison the effect of lung Mechanical Ventilation parameter、cytokine level and blood gas analysis、lactate、electrolytes level. Results After 24h CBP, the lung Mechanical Ventilation、PH and PaO2、cytokine level prameter improved apparently in bicarbonate group and lactate group. Contrast bicarbonate group and lactate group after 24h CBP,no difference in Arterial partial pressure of oxygen、Arterial blood lactate、Serum electrolytes level.The PH in lactate group was higher than bicarbonate group（7.39±0.05 vs 7.30±0.01,p＜0.01）.The PaCO2 level was lower in lactate group than bicarbonate group（mmHg:57.14±5.04 vs 89.00±3.66,p＜0.01;1mmHg=0.133kPa）.Conclusion Combine CBP might improve the lung Mechanical Ventilation parameter、cytokine level and blood gas analysis quickly than conventional therapy in severe asthma treatment.The lactate displacement liquid improve the retention of carbon dioxide.（