fhh第8章作用于生殖系统药物.ppt

生殖系统用药：regulating or controlling the reproductive system . ;翘馆办冬孟熔塞裳松勤挨交诛豢英拿姜奈洞韦妈枫敷颈柑棍屹爸代吮棚刮fhh第8章作用于生殖系统药物fhh第8章作用于生殖系统药物;第一节 生殖激素类药物;Estradiol (natural hormone)： Estradiol esters (eg,cypionate, or benzoate) have a longer duration of action than the parent compound. 药理作用： for gonad (生殖器官）: 促进性器官形成；促进子宫生长；增强子宫收缩力。 induction of fertile estrus 刺激乳房发育和泌乳。 促进蛋白质合成;应用： 治疗胎衣不下，排出死胎和子宫内的炎性物质 诱导泌乳 used in dogs, cows for induction of fertile estrus treatment of urinary incontinence（小便失禁） in bitches （母犬） for antitumor activity in prostatic and perianal tumors （前列腺瘤和直肠瘤）;Adverse effect bone marrow suppression and potentially fatal aplastic anemia (再生障碍性贫血）in dogs and cats; its use is also associated with development of endometrial （子宫内膜）hyperplasia in dogs and cats, and it may have teratogenic effects in pregnant animals. ;药理作用 抑制子宫收缩 inhibit the release of Gonadotropin-releasing hormone, Gonadotropins, suppress estrus 刺激乳腺腺泡的生长 应用 治疗习惯性或先兆性流产 母畜同期发情 抑制发情 ;Androgen drug; Methyltestosterone （甲基睾丸素） 作用：促进雄性器官发育，促进蛋白质合成。 应用：used for estrus suppression in female dogs and used for cryptorchidism （隐睾）in male animals.;Testosterone propionate Nandrolone phenylpropionate: 蛋白同化剂， anabolic effects in convalescing or athletic animals。用于治疗组织分解旺盛的疾病如严重寄生虫病，也用于组织修复、体弱动物的恢复等。 禁用于促进食品动物的生长。;Gonadotropins (促性腺激素）;Follicle-stimulating hormone (FSH) 药理作用 母畜：刺激卵泡颗粒细胞增生和膜层的生长发育；与LＨ 合用，促进卵泡成熟和排卵，使卵泡内膜分泌雌激素。 公畜：促进生精上皮发育和精子生成。 应用： used for superovulation of several domestic species. application in induction of fertile estrus in bitches.; luteinizing-hormone(LH) 作用 母畜：与FSH协同促进卵泡成熟、排卵，形成黄体 公畜：促进睾丸间质细胞分泌testosterone, 与FSH协同促进精子生成。 应用： used for the treatment of ovarian cysts (囊肿） in cattle or dogs induction of ovulation;Pregnant Mare Serum gonadotropin (PMSG) 作用 femal：FSH-like effects in animals; male: LH-like effects 应用： used for ovulation induction and for estrus induction for superovulation;Human chorionic gonadotropin(HCG) 作用：exerts mainly luteinizing-hormone　like effec