期刊Study on gamma and electron beam sterilization of third generation cephalosporins cefdinir and cefixime in solid state.pdfVIP

ARTICLE IN PRESS Radiation Physics and Chemistry 79 (2010) 1079–1087 Contents lists available at ScienceDirect Radiation Physics and Chemistry journal homepage: /locate/radphyschem Study on gamma and electron beam sterilization of third generation cephalosporins cefdinir and cefixime in solid state Babita K. Singh a,n, Dilip V. Parwate a, Indrani B. Das Sarma b, Sudhir K. Shukla c a Department of Chemistry, RTM Nagpur University Campus, Amravati Road, Nagpur 440033, India b Jhulelal Institute of Technology, Nagpur, India c Central Forensic Science Laboratory, Chandigarh, India a r t i c l e i n f o a b s t r a c t Article history: The effect of gamma radiation from 60Co source and 2 MeV e-beam was studied on two thermolabile Received 14 September 2009 cephalosporin antibiotics viz cefdinir and cefixime in solid state. The parameters studied to assess radiolytic Accepted 28 April 2010 degradation were loss of chemical and microbiological potency, change in optical rotation, electronic and vibrational absorption characteristics, thermal behavior and color modification. ESR spectroscopic study, HPLC Keywords: related impurity profile, thermogram and Raman spectrum are applied in deducing the nature of radiolytic Radiosterilization impurities and their formation hypotheses. Cefixime is radiation sensitive, whereas cefdinir has acceptable Cephalosporin