期刊Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules.pdfVIP

AAPS PharmSciTech 2005; 6 (4) Article 73 (). Comparison Between Gamma and Beta Irradiation Effects on Hydroxypropylmethylcellulose and Gelatin Hard Capsules Submitted: March 24, 2005; Accepted: September 17, 2005; Published: December 1, 2005 Francesco Cilurzo,1 Francesca Selmin,1 Paola Minghetti,1 Luisa Montanari,1 Cristina Lenardi,2 Francesco Orsini,2 and Giulio Poletti2 1Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Milano, viale Abruzzi 42, 20131, Milano, Italy 2Istituto di Fisiologia Generale e Chimica Biologica, Università degli Studi di Milano, via Trentacoste 2, 20134, Milano, Italy ABSTRACT pharmaceutical and medicinal herbal products as well as health food and botanical health products. Nevertheless, The effects of electron beam or γ-irradiation on technologi- irradiation has to be permitted only when it has been ex- cal performances (capsule hardness, expressed as deform- perimentally proved and well documented that no harmful ing work and dissolution time) of empty 2-shell capsules side effects occur, owing to possible qualitative and quan- made of gelatin or hydroxypropylmethylcellulose (HPMC) titative alterations of the irradiated materials. were studied. Capsule structural changes induced by ra- diation treatment were investigated by capillary viscometry γ-rays emitted from nuclear source (60Co or 137Ce) or and atomic force microscopy (AFM). The capsules were e