第十一章 广谱抗菌药左氟沙星.pdfVIP

广谱抗菌药左氟沙星 41 3　李 珊, 傅 鹰, 朱永珙 全国药品不良反应重点监 4　Kess per DA. M ED w atch : T he new FDA m edi 察医院第一次工作会议在京召开 药物流行病 cal p roducts repo rting p rogram. A m J H osp ( ) 学杂志, 1995; 4 1 : 63 P harm 1993; 50: 1151 The Effect of D rug M on itor ing for Prescr iption To OTC 1 2 Chen L unqing　Q ian Songjun 　Zhou J in sheng T he P eop le ’s H osp ita l of S u in ing Coun ty , S u in ing 221200 1 　 T he 14th Institu te of the M in istry of E lectron ic Ind ustry ,N anj ing 210037 　2 T he N o. 180 H osp ita l of F uz hou Com m and , Q uanz hou 362000 Abstract　T h is essay describes the effect of drug m on ito ring fo r p rescrip tion (R x ) to O TC. In o rder to develop O TC , it is one of the im po rtan t m easu res to strengthen the super vision of the drug and p rom o te the change from R x to O TC. In Ch ina, som e ach ievem en ts have been m ade in the drug m on ito ring , bu t the m anagem en t system of drug m on ito ring has to be perfected and the advanced fo reign m odes of m anagem en t have to be learned. 　 　 　 Key W ords　P rescrip tion O TC D rug monito ring A dverse drug reaction ( 收稿: 广谱抗菌药左氟沙星 李　眉 (卫生部药品审评中心　北京　100050) 摘　要　左氟沙星为氧氟沙星的光学活性体, 其体外抗菌活性是氧氟沙星的两倍, 且口服吸 收良好, 临床上对各种感染性疾病有满意的疗效, 毒副作用小。本文叙述了左氟沙星的制备工艺、 体内外抗菌作用、毒性、药代动力学和临床应用。 关键词　左氟沙星　抗菌活性　毒性　药代动力学　临床疗效 ( ( ) (