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duringfetalontogeny创新.PDF

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Cardiovascular Research (2015) 107, 352–363 SPOTLIGHT REVIEW doi:10.1093/cvr/cvv146 Development and trafﬁcking function of haematopoietic stem cells and myeloid cells during fetal ontogeny Kristina Heinig1†, Fanny Sage2†, Catherine Robin2,3‡, and Markus Sperandio1‡* 1Walter-Brendel-Center of Experimental Medicine, Ludwig-Maximilians Universita¨t, Marchioninistr. 15, Munich 81377, Germany; 2Hubrecht Institute–KNAW University Medical Center Utrecht, Utrecht, The Netherlands; and 3Department of Cell Biology, University Medical Center, Utrecht, The Netherlands Received 16 December 2014; revised 26 March 2015; accepted 16 April 2015; online publish-ahead-of-print 18 May 2015 Abstract Fetal haematopoiesis is a highly regulated process in terms of time and location. It is characterized by the emergence of speciﬁc cell populations at different extra- and intraembryonic anatomical sites. Trafﬁcking of haematopoietic stem cells (HSCs) between these supportive niches is regulated by a set of molecules, i.e. integrins and chemokine receptors, which are also described for the recruitment of differentiated innate immune cells. In this review, an overview will be given on fetal haematopoiesis as well as trafﬁcking of HSCs during fetal life. In addition, we will focus on the appear- D o