杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响论文.docVIP

　　杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响论文 段连宁 韩红星 刘静 阎洪敏 朱玲 薛梅 丁丽 朱培瑜 王恒湘 纪树荃 【摘要】 本研究分析杀伤细胞免疫球蛋白样受体（killer cell Iglike receptor, KIR）及其配体分子相合与否对单倍体相合骨髓移植效果的影响。 分析了74例KIR基因及其配体分子HLACpact of Inpatible Killer Cell Immunoglobulinlike Receptor and Its Ligand on the OUte of Haploidentical pared uch stronger reactions betalignant hematological disease because the antileukemia effect (GVL) induced by donor derived T cells ost popular measure to promote engraftment and inhibit GVHD is still by the blockade of T cell activation or by T cell inhibition/depletion in vivo. But the GVL effect induced by donor derived T cells is also easures. A novel research about the NK immunologicallike receptor found that NK cells can exert the homogeneous antileukemia effect through an overall different mechanism. Donorderived homoreactive NK cells played a key role in improving the effect of BMT［1］. More research folloe thing to do in preventing GVHD, initiating and promoting the engraftment and inducing the antileukemia effect. The KIR expressed on the surface of NK cells played an important role during the process［2-5］. KIR is a member of immunologicallike superfamily expressed on NK cells ely inhibitory group (possessing a cytoplasmic tail bearing immunoreceptor tyrosinebased inhibitory motifs, ITIMs) and activating group (through adaptor protein to generate intracellular signals via immunoreceptor tyrosinebased activating motifs, ITAMs) munological effect. If the KIR ligand issing betissing self） the NK cells could display heterogeneity even homogeneity reactive potential to facilitate GVL and decrease relapse, GVHD and transplantation failure and prolong overall survival (OS) rate［1，2］. Therefore the genotyping of KIR and its ligand had been given more and more emphasis recently by the scientists engaging in BMT. Up to noong them the inhibitory KIR genotypes uch more attention because of their relations ate the BMT effects by analyzing the patibility of KIR and their liga