外语文献山师模板.pptx

汇报人：赵 新 日 期：2016年12月21日  School of Life Science Artemisinin concentration and antioxidant capacity of Artemisia annua distillation byproduct 黄花蒿蒸馏副产物中青蒿素的浓度和副产物的抗氧化能力  CONTENTS CONTENTS Contents Background Materials and methods Results Conclusion Background 青蒿素(artenmisinin)青蒿素是从复合花序植物黄花蒿（Artemisia annua L.，即中药青蒿）叶中提取得到的一种无色针状晶体分子式为C15H22O5。 属倍半萜内酯，具有过氧键和6-内酯环 倍半萜（sesquiterpenes）是指分子中含15个碳原子的天然萜类化合物。如按倍半萜结构的含氧基分类，则便于认识它们的理化性质和生理活性，例如倍半萜醇、醛、内酯等。 青蒿素曾被世界卫生组织称做是“世界上唯一有效的疟疾治疗药物”。对折磨人类和牲畜的病原虫均有高效的对抗作用。 根据世卫组织的统计数据，自2000年起，撒哈拉以南非洲地区约2.4亿人口受益于青蒿素联合疗法，约150万人因该疗法避免了疟疾导致的死亡。因此，很多非洲民众尊称其为“东方神药”。 2016年12月1日，在线发表于美国Cell（《细胞》）杂志上的一项突破性研究表明，这一药物或许还可以拯救数亿糖尿病患者。 Background 黄花蒿（Artemisia annua）不仅是工业生产青蒿素的唯一来源。在黄花蒿植物体内包含一种散发芳香气味的精油物质（ essential oil ），在化妆品的制作上具有重要的使用价值。 文章创新点：但是至今为止，与黄花蒿多用途的叶生物量青蒿素含量，精油产量和抗氧化剂（ antioxidants ）的能力却没有被研究过。本研究的目的是评估蒸馏时间与叶生物量蒸馏残留物（ plant residue from distillation (PRD) 中精油产量，青蒿素含量和抗氧化物能力的关系 结果表明：叶生物量（ leaf biomass ）可以用作精油和抗氧剂的开发，但植物蒸馏残留物中并不含有青蒿素。 实际应用：蒸馏残留物的高抗氧化能力表明，用于精油生产的副产品，可作为潜在的抗氧化剂来源，可实际应用于牲畜饲料的成分物质，也可作为保健品制作的化学来源 Materials Artemisia annua plants were grown during the 2008–2010 growing seasons The experiment was initiated in the spring of 2008. When seedlings reached approximately 12cm in height, they were transplanted into previously prepared raised beds coveredwith black plastic mulch. Plants obtained in 2009 and 2010 were developed through reseeding from plants grown in the previous year. In 2010, A. annua plants were harvested in October and the essential oil was extracted from biomass via steam distillation Immediately after the harvest,primary branches were eparated from the main stems and the main stems discarded. Representative subsamples (500 g) of branches not thicker than 2 mm, with leaves, were used for steam distillation and extractionof the essential oil. The distillation times were 1.25, 2.5, 5, 10, 20, 40, 80, 160,and 240 min. An undistilled sample (0 min distillation) was kept as