联合检测CYFRA22.docxVIP

联合检测CYFRA21 作者：朱红 张光彩 蒋玉敏 黄祥磊 【摘要】 目的：检测血清CYFRA21-1、CA125、 CEA、NSE、的水平，探讨其在肺癌鉴别诊断中的价值。方法：115例肺癌和41例良性肺疾病患者血清中CYFRA21-1、CA125、CEA、NSE、的水平，采用t检验对数据结果进行统计分析。结果：肺癌组CA125、CEA、CYFRA21-1测定水平明显高于肺良性病变组（P＜0.01）。肿瘤标记物测定水平与病理类型有关，血CEA、CA125以腺癌最高，血NSE以小细胞肺癌最高，血CYFRA21-1以鳞癌最高。结论：４项肿瘤标记物联合检测有利于肺癌的鉴别诊断。【关键词】 肺癌 肿瘤标记物　 Abstract： Objective： To measure the levels of serum CYFRA21-1、CA125、CEA and NSE of patients with lung cancer and those with benign lung diseases,and to evaluate the clinical diagnostic value of　combined detection of serum CEA, CYFRA21-1、CA125 and NSE in patients with lung cancer.　Method：Serum CEA, CYFRA21-1、CA125 and NSE levels were determined by chemiluminescence immunoassay in 115 patients with lung cancer,41patients with benign pulmonary diseases.The data was analyzed by t test. Result： The serum levels of CEA、CYFRA21-1、CA125 and NSE were significantly higher than that in those with benign lung diseases. The levels of serum CYFRA21-1、CA125、CEA, and NSE were related to types of pathology.The highest levels of CEA and CA125 appeared in adenocarcinoma,small cell carcinoma and squamous cell carcinoma,respectively.The highest level of serum of NSE appeared in patients with small cell carcinoma. However, The serum levels of CYFRA21-1 in patients with squamous cell carcinoma were highest.Conclusion： Combined determination of serum levels of CEA, CYFR21-1、CA125 and NSE is valuable in differential diagnosis of lung cancers.  　　Key words: Lung neoplasms; Tumor markers 　　肺癌是临床上最常见的肿瘤之一，有时其与良性肺部疾病难进行鉴别诊断，以致影响治疗时机。肿瘤标记物是由肿瘤细胞的基因表达而合成分泌的或是由机体对肿瘤反应而异常产生和并升高的物质。检测肿瘤标记物对肿瘤的早期诊断、观察评价治疗效果及判断预后具有重要意义，但至今尚未找到一种特异性强，敏感性高，能使肿瘤早期发现的肿瘤标记物。为此我们联合CEA, CYFRA21-1??CA125 和NSE 对肺癌及肺良性疾病患者进行测定，以探讨它们在肺癌鉴别诊断中的价值。　　1 资料与方法　　1.1 一般资料：所选病例均为2005年10月至2006年12月住院患者。分为两组，肺癌组共115例，均经手术及病理证实，并明确分期，男86例，女29例，年龄30～80岁，鳞癌46例，腺癌44例，小细胞癌10例，其他15例。肺部良性病变组共41例，均经临床、手术或病理证实，男27例，女14例，年龄30～80岁，肺部炎性病变26例，肺结核瘤8例，血管瘤2例，结节病2例，肺血管平滑肌瘤3例，支气管囊肿2例。　　1.2 检测方法：受检者均