还原响应型药物载体研究进展.pdfVIP

·1032 · 药学学报 Acta Pharmaceutica Sinica 2011, 46 (9): 1032−1038 还原响应型药物载体的研究进展 * 唐忠科, 熊兴泉, 蔡 雷, 徐源鸿 (华侨大学材料科学与工程学院, 福建省高校功能材料重点实验室, 福建 厦门 361021) 摘要: 还原响应型药物载体以其高效快速释放药物、毒副作用小、可生物降解的优良特性, 逐渐成为药物载 体领域研究的热点, 也是最具临床应用潜力的智能药物载体之一。本文综述了还原响应型药物载体研究的必威体育精装版 进展, 包括还原响应的药物、基因与载体的偶联物及还原响应的纳米聚合物胶束、纳米囊泡、纳米中空微球、 纳米脂质体等的合成和药物释放的机制以及各类载体的优缺点, 为其在药剂学中的进一步应用提供理论依据。 关键词: 还原响应; 药物载体; 二硫键; 药物释放 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (2011) 09-1032-07 Recent progress in the study of reduction-sensitive drug carriers * TANG Zhong-ke, XIONG Xing-quan , CAI Lei, XU Yuan-hong (College of Materials Science and Engineering, Huaqiao University, Key Laboratory for Functional Materials of Fujian Higher Education, Xiamen 361021, China) Abstract : With rapid and efficient drug release, few side effects and excellent biodegradable properties, the reduction-sensitive carriers is not only the new hot point in the field of pharmaceutical research, but also the most promising intelligent drug carrier on clinical application. This paper reviews the latest research of reduction- sensitive drug and gene carriers, including the mechanisms of drug release and the synthesis of the reduction- sensitive conjugates, reduction-sensitive nano polymer micelles, nano vesicles, nano hollow microspheres, nano liposomes, as well as the characteristics and advantages of various kinds of carrier system. It will provide a theoretical basis for its further application.