麻疹病毒属相关自噬研究进展.PDFVIP

微生物学通报 May 20, 2017, 44(5): 1189−1195 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.160454 专论与综述 麻疹病毒属相关自噬的研究进展 梁忠祥 朱学亮 张志东 窦永喜* ( 730046) 摘 要：自噬是一种复杂的细胞内生物学过程，受众多基因调控，存在复杂的调控网络，在不 同组织器官、生理和病理状态所起的作用也不同。对20 多个病毒科的50 多种DNA 或RNA 病 毒的研究发现自噬是把双刃剑，但在研究麻疹病毒属病毒自噬相关内容时发现自噬有利于病毒 的复制与传播，并且H 和F 蛋白在麻疹病毒属诱导自噬方面发挥着重要作用。麻疹病毒能够通 过RNA 病毒诱导自噬的关键调控分子IRGM 诱发自噬，并且CD46 作为麻疹病毒属的受体分 子，在诱导自噬发生方面发挥了至关重要的作用。此外，麻疹病毒属病毒诱发的自噬与其引起 的免疫抑制之间可能存在密切关系。本文为麻疹病毒属的免疫学研究提供了参考。 关键词：自噬，麻疹病毒属，受体，信号通路 Progress in morbillivirus-related autophagy * LIANG Zhong-Xiang ZHU Xue-Liang ZHANG Zhi-Dong DOU Yong-Xi (State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China) Abstract: Autophagy is a complex intracellular biological process, which is regulated by a complex regulatory network involved in a large number of regulatory genes, and plays different roles depending on different tissues and organs, physiological and pathological states. In this review, the research progress in morbillivirus-related autophagy, especially the signal pathway of autophagy induced by the viruses is summarized. Studies on more than 20 families of viruses, and more than 50 different DNA or RNA viruses indicated that autophagy is a double-edged sword to a virus. In morbilliviruses, autophagy is critical for viral replication and spread. It was found that the viral