药理学复习提.docVIP

第 一部分 总论 Part 1 General Principles 学习导航：总论部分包括1-7章；该部分的学习目的为掌握药理学的基本概念；熟悉与药理学基本概念相关的知识；了解药动学与药效学的相关公式与知识。 Learning guide: General Principles comprise chapter 1-7. The purpose of the study in this part is to master the basic concepts of pharmacology, familiarize with the knowledge related to these concepts, understand the formula correlated with pharmacokinetics and pharmacodynamics. 第一章　绪言 掌握药物与药理学的概念；熟悉药理学的研究对象、任务与方法, 按危机与药物的关系，以及药理学的学习方法。 Chapter 1 Introduction Understand the concepts of pharmacology and drug and the purpose of learning pharmacology; Beware of the research object, task and methodology of pharmacology, the relationship between drug and placebo, and the way to study pharmacology. 第二章　药物代谢动力学 掌握药物代谢动力学、首关效应、肝肠循环、生物利用度、一级消除动力学、零级消除动力学、半衰期、表观分布容积及清除率的基本含义与意义。 熟悉药物吸收的概念与影响因素、与血浆蛋白结合对药物作用的影响、肝脏细胞色素P450酶、药酶的诱导与抑制, 药物生物转化与影响因素。 了解 Handerson-Hasselbalch公式的应用、房室模型、药物分布的概念及影响因素（血脑屏障等）、药物转化类型、药物的跨膜转运机制（被动转运与载体转运）药物排泄途径与机制、时量曲线、多次给药的时量曲线和稳态浓度、不同给药剂量与给药间隔时间对稳态浓度的影响。 Chapter 2 Pharmacokinetics Understand the following important concepts: first-pass elimination, bioavailability, clearance, apparent volume of distribution, compartment model, drug plasma half-life, first-order kinetics and zero-order kinetics Beware of the concepts of absorption and factors affecting absorption, the consequence of plasma-drug binding, biotransformation and the factors affecting biotransformation, e.g., hepatic microsomal mixed function oxidase system. Know the application the formula of Handerson-Hasselbalch, the concepts of the One and Two compartment Model, drug membrane transfer (active and passive), drug distribution and related factors, e.g., Blood Brain Barrier concentration-time relationship and concentration-time curve, drug kidney excretion, concentration-time curve of continuous administration and relationship between multiple dosage and drug steady state concentration. 第三章　药物效应动力学 掌握药物效应动力学、药物作用与药理效应、药物与受体的亲和力与内在活性、激动药、完全激动药、拮抗药、竞争性拮抗药、非竞争性拮抗药、药物作用