血管新生_治疗心血管疾病的新策略.pdfVIP

中国中西医结合杂志2006 年 2 月第 26 卷第 2 期 CJ ITWM , February 2006 , Vol. 26 , No. 2 1·73 · ·学术探讨· 血管新生 ———治疗心血管疾病的新策略 王培利 雷 燕 陈可冀 摘要 血管新生是在原来存在的血管结构上长出新血管的生物学过程。血管内皮生长因子、成纤维细 胞生长因子等许多因素均可刺激新生血管的形成。促进缺血心肌血管新生已成为治疗缺血性心血管疾病的 新策略。近年来研究者对血管新生基础研究及临床试验进行了深入研究并取得良好效果。同时 ,治疗心血 管新生亦存在一些尚需解决的问题。中医药益气活血、祛瘀生新等许多治疗法则以及临床的有效性 ,是中医 药血管新生研究的理论和临床依据。 关键词 血管新生 ;缺血性心脏病 ; 中医药;治疗策略 Angiogenesis ———A Novel Thera peutic Strategy for Cardiovascular Diseases WAN G Peili , L EI Yan , and CHEN Keji Xiyuan Hospital , China A cadem y of Chinese Medical Sciences , Beijin g ( 10009 1) Abstract Angiogenesis is a biological process of growing new vessels from the existed vascular structure. Many factors , such as vascular endothelia growth factor and fibroblast growth factor , can stimulate the forma tion of new vessels. Promoting revascularization in ischemic myocardium has been a novel therapeutic strategy for ischemic cardiovascular diseases. Recently , investigators have done a lot of work in experimental researches and clinical trials , and made some pro gress. Nevertheless , there are still some problems to be solved in therapeu tic angiogenesis. Clinical validity of traditional Chinese medicinal treatment and its therapeutic principles includ ing strengthening qi and activating blood , removing blood stasis to stimulate generation of blood , etc. are the theoretic and clinical basis for TCM study on angiogenesis. Key words angiogenesis ;ischemic cardiovascular diseases ;traditional Chinese medicine ;therapeutic strategy ( ) 血管新生 angiogenesis 已成为目前世界医学领域 的治疗策略 ,即通过刺激心肌缺血区小血管生长和侧 的热点课题。深入研究血管新生的内在机制以及开发 枝循环的形成 ,实现心肌缺血区的自我搭桥。因此 ,治 有效的血管新生药物 ,必将有益于心血管疾病的防治。 疗心血管新生已成为一种旁路生物学策略 ,这对相当 中医药益气活血、祛瘀生新等许多治疗法则以及临床