糖尿病冠心病患者血清甘油三酯水平的变化.docVIP

糖尿病冠心病患者血清甘油三酯水平的变化 　　作者：王学东 丛海霞 李家 杜立杰 陈金玲 苏伟　作者单位： 100260 北京仁和医院心内科 　　【摘要】 目的 分析糖尿病冠心病患者的血清甘油三酯水平，并探讨其临床意义。方法 61例经冠状动脉造影证实的冠心病患者，男22例，女39例;年龄28～78岁，平均年龄(58.46±10.55)岁。按有无糖尿病分为两组：糖尿病冠心病组和非糖尿病冠心病组。酶反应速率法测定其空腹血清甘油三酯水平。结果 糖尿病冠心病组的甘油三酯水平明显高于非糖尿病冠心病组(P0.05)，两组之间的血总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇，统计学上差异均无显著性(P0.05)。结论 糖尿病冠心病患者的血清甘油三酯水平明显增高，在一定程度上可能加重或促进了冠状动脉粥样硬化的发生，但其作用机制还有待于进一步研究。 　　关键词 糖尿病 冠心病 甘油三酯 　　Changes of the level of triglyceride in diabetes mellitus with coronary heart disease 　　Wang Xuedong,Cong Haixia,Li Jialiu,et al. 　　Department of Cardiology,Beijing Renhe Hospital,Beijing 102600. 　　【Abstract】 Objective To analyze the changes of the serum triglyceride level in diabetes mellitus(DM) patients with coronary heart disease(CHD)，and to explore its clinical significance.Methods 61 patients with coronary heart disease confirmed by coronary angiography(CAG)were enrolled.There were 22 males and 39 females.The average age was (58.46±10.55) years (range,22 to 78 years old).They were divided into two groups according to with or without DM:DM group and non-DM group.The serum level of triglyceride was determined by the method of enzyme reaction rate.Results Compared with that of non-DM group,the serum level of triglyceride in DM group increased significantly(P0.05).Whereas there were no significant differences of the level of total cholesterol,LDL-C and HDL-C between DM group and non-DM group(P0.05).Conclusion The serum level of triglyceride in CHD patients with DM increase highly,which may have aggravated or promoted the development of atherosclerosis to some extent,but the mechanism of this role needs to be further studied. 　　Key words diabetes mellitus coronary heart disease triglyceride 　　本研究旨在分析伴糖尿病的冠心病患者空腹血清甘油三酯水平的变化，并探讨这一变化的临床意义。 　　1 资料与方法 　　1.1 一般资料 研究对象选自2003年6月～2004年5月在本院行选择性冠状动脉造影和经皮冠状动脉介入治疗的冠心病患者，共61例，其中男22例，女39例;年龄28～78岁，平均(58.46±10.55)岁。按有无糖尿病分为两组：糖尿病冠心病组(33例)和非糖尿病冠心病组(28例)。冠心病以冠状动脉造影证实至少有一支血管管腔狭窄程度超过50%作为标准。糖尿病的诊断参照1997年美国糖尿病