北京地区临床无前列腺癌人群年龄相关性前列腺特异性抗原地参考范围.pdfVIP

·1704 · doi 10.3969/j.issn. 1673-4254.2013.11.32 J South Med Univ, 2013, 33(11): 1704-1708 临床研究 北京地北京地区临床无前列腺癌人群年龄相关性前列腺特异性抗原的区临床无前列腺癌人群年龄相关性前列腺特异性抗原的 参考参考范围范围 刘 欣，王 节，张舜欣，林 倩 解放军总医院南楼临床部超声科，北京 100853 摘要：目的探讨前列腺特异性抗原（PSA）在不同年龄段临床无前列腺癌人群中的参考值范围，以提高PSA 在前列腺癌筛查中 的诊断准确性。方法 自2010 年4 月~2011 年10月来我院进行正常健康查体的1611例成年男性为参与者。所有参与者均接受 前列腺特异性抗原抽血检查、肛门指检（DRE）及经直肠超声（TRUS）检查。以上三项检查任何两项出现异常者，行前列腺穿刺 活检。最终共有1572位无前列腺癌者纳入本研究。按年龄分为5组，40~49 岁、50~59 岁、60~69 岁、70~79 岁、≥80岁。结果 中 位数（95%分位数）分别为：40~49 岁为0.506（1.565），50~59 岁为1.04（2.920），60~69 岁为1.16（4.113），70~79 岁为1.34（5.561）， 80 岁以上为2.975（7.285）。按年龄从低至高各组的25%分位数至75%分位数分别为0.343~0.923 ，0.663~ 1.580 ，0.693~2.203 ， 0.789~2.368、1.188~4.295。前列腺特异性抗原与年龄呈正相关（r=0.314 ，P0.001）。结论 在前列腺癌筛查时，对不同年龄段的 人使用不同的血清PSA 参考值范围，能提高其诊断准确率，但不同民族和地区应选择适合本地区人群的血清PSA 参考值。 关键词：年龄；前列腺癌；前列腺特异性抗原 Age- related reference ranges of serum prostate- specific antigen in men free of prostate cancer in Beijing LIU Xin, WANG Jie, ZHANG Shunxin, LIN Qian Department of Ultrasound, Nanlou Clinical Medicine Division, General Hospital of PLA, Beijing 100853, China Abstract: Objective To determine the age-related normal ranges of serum prostate-specific antigen (PSA) level in men free of prostate cancer in Beijing. Methods Form April 2010 to October 2011, 1611 healthy men undergoing routine physical examinations in our hospital were enrolled and received examinations with serum PSA test, digital rectal examination and transrectal ultrasound. The men with abnormalities in any two of the three examinations were referred to a prostate biopsy. The men with normal results in any two of the examinations or with a negative biopsy finding were defined as men without prostate cancer. Men with a prior history of prostate cancer/surgery or with urinary tract infection/obstruction were excluded. Results A total of 1572 men without prostate canc