睫状神经营养因子对应激引起行为障碍的作用.pdfVIP

中国行为医学科学2000 年第 9 卷第 2 期 ·81 · ·论　　著· 睫状神经营养因子对应激引起行为障碍的作用 严　进　路长林　何　成　王雪琦　黄爱军　王成海 【摘要】　目的　探讨睫状神经营养因子对应激引起行为障碍的作用。方法　采用 open field 测定, 观察急性和慢性足底 电击应激大鼠的open field 行为变化, 及双侧海马注射睫状神经营养因子对其影响。结果　急性应激大鼠open field 行为活动 增加, 慢性应激大鼠 open field 行为活动减少; 睫状神经营养因子对对照组大鼠和急性应激大鼠的open field 行为无明显作 用, 但可显著改善慢性应激大鼠的行为障碍。结论　适宜浓度的睫状神经营养因子可改善慢性应激大鼠的行为障碍。 【关键词】　睫状神经营养因子　应激　 开场行为 Effects of c iliary neurotroph ic factor on behav ioral d isorder induced by chron ic stress in rat Y an J in , L u Chang lin, H e , , , 200433 Cheng et al D ep t of N eu robiology S econd M ilitary U niversity S hang hai 【 】 ( ) Abstract Objective To investigate the effects of ciliary neuro troph ic facto r CN T F on behavio ral diso rder induced by stress in rat M ethods T he irregular ligh t and foo tshock sw ere app lied to rats fo r 7 days w ith first day as acute stress and final 0 - 1 , 100 - 1 , 500 - 1 1000 - 1 day as ch ronic stress T he effects of U l U l U l and U l CN T F adm inistrated daily into bilateral h ippocampus befo re stress on the changes w ere observed by open field test Results T he open field behavio rs w ere increase during acute stress and decrease during ch ronic stress in rats A ny concentration of CN T F adm inistratedinto bilateral 500 - 1 1000 - 1 h ippocampus had no effect to behavio rs in contro l and acute stressful rats But U l and U l CN T F significantly 500 - 1 1000 - 1 raised dep ressive behavio r induced by ch ronic stress Conclusion U l and U l CN T F could imp rove behavio ral diso rder induced by ch ronic