PROSPER-SMALL研究课件(PPT 8页).ppt

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PROSPER-SMALL研究课件(PPT 8页)

PURSUIT Impact on myocardial muscle preservation * PURSUIT Platelet IIb-IIIa in Unstable angina: Receptor Suppression Using Integrilin? (eptifibatide) Therapy PURSUIT Death or MI composite within 30 days % Patients with composite events 16.2% 12.8% Angiography within 72 hrs 3.4% ? (p=0.005*) 16.8% 11.8% 5.5% 1.8% 33.5% 18.4% PCI within 72 hrs 5.0% ? (p=0.01*) MI prior to PCI within 72 hrs 3.7% ? (p=0.001*) CABG within 72 hrs 15.1% ? (p=0.001*) * Post-randomization analysis PURSUIT Death or MI composite at 30 days in patients undergoing PCI within 2, 4, or 6 hours of randomization % Patients with composite events 16.5% 9.1% 16.1% 9.7% 15.1% 9.5% PCI within 2 hours 7.4% ? PCI within 4 hours 6.4% ? PCI within 6 hours 5.6% ? (n=79) (n=66) (n=118) (n=103) (n=139) (n=127) Not powered for statistical analysis PURSUIT Death or MI composite within 30 days in transferred patient population % Patients with composite events 23% 18% 21% 15% 29% 26% Transferred population 5% ? U.S. transferred population 6% ? Non-U.S. transferred population 3% ? (n=429) (n=310) (n=119) Not powered for statistical analysis. PURSUIT Death or MI composite within 30 days based upon time from onset of symptoms % Patients with composite events 17.5% 14.7.% 15.8% 13.5% 15.4% 14.0% 6 hrs 2.8% ? 6-12 hrs 2.3% ? 12 hrs 1.4% ? All MIs 13.6% 12.6% * CK-MB (x upper limit of normal) Placebo (n=4,739) Eptifibatide 180/2 (n=4,722) ( 10 2.0% 1.6% 5 to 10 2.7% 1.9% 3 to 5 1.5% 1.1%

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