氯氮平仿单(国外英文资料).docVIP

氯氮平说明书 Chlorazo flat sheet specification 【 drug name 】 Universal name: chlorazepine tablet The former name: The commercial name: English name: Clozapine Tablets Chinese pinyin: Ludanpin Pian The main constituent of this product is clozapine, whose chemical name is 8-chloro-11 - (4-methyl-1-piperazine) -5h Diphenyl and [b, e] [1, 4] diazo. The formula is: C18H19ClN4 326.84 【 properties 】 This is a pale yellow. [pharmacological toxicology] Benzodiazepine diphenyldiazepam antipsychotics. For the cerebrum serotonin (5-ht2a) receptor and many The blocking of the DA1 receptor is strong and has a blocking effect on the dopamine (DA4) receptor, right Dopamine (DA2) receptors have a weak blocking effect, as well as anticholinergic (M1), antihistamine (H1) and Resistance? Norepinephrine receptors, which are rarely seen in the outside of the cone, generally do not cause increased prolactin in the blood. Can inhibit the brain stem network structure ascending activation system directly, have the powerful sedation hypnotic effect. [pharmacodynamics] The absorption rate and degree of the food are not affected by the absorption rate and the degree of absorption The biological use of cloth to tissues was large, with an average of about 50% to 60%, with the liver first effect. The amount of plasma peak is 3.2 hours (1 ~ 4 hours), eliminating half-life (t1/2?). Average 9 hours (3.6 to 14.3) Hours), the surface distribution volume (Vd) 4.04 ~ 13.78 L/kg, the combination rate is high. It is metabolized by the liver, 80% In the form of metabolites in urine and feces, the main metabolites are N - to methyl clozapine and clozapine N - oxide, etc. At the same dose and weight, the serum drug concentration of women was clear Higher than the male patient, smoking can accelerate the metabolism of the product, and the removal rate and metabolism of the kidney are significantly reduced in the elderly. This product can be secreted from milk and can be passed through the blood-brain barrier. 【 ind