干细胞标记物(国外英文资料).docVIP

干细胞标志物 Stem cell markers Markers of embryonic stem cells? Oct-4: oct-4 (also called oct-3 or oct3/4) is a member of the POU transcription factor, initially identified as the DNA binding protein, which can be activated by the cis component. It is expressed in universal embryonic stem cells (ES) and reproductive cells. This expression is necessary to maintain self-renewal and pluripotency of stem cells. The differentiation of ES leads to the reduction of oct-4. Oct-4 is not only the main regulatory factor for the multiple differentiation of cell lines, but also the first to identify the all-powerful ES cells. SSEAs: SSEAs was originally used to identify the three monoclonal antibodies that identify sugar lipids. The ssea-1 expression was expressed in the embryonic surface of the embryonic stem (e.g. 8 cell period) and also found in the surface of the teratoma stem cells, but not in the differentiated derived cells. The tubal epithelium, endometrial, epididymis, and the adult rat brain and the renal tubule area also found a response to the ssea-1 antibody. SSEA - 3 and 4 are synthesized when the egg occurs, in oocyte, zygote and early follicle cell membrane. The biological function of these molecules associated with the sugar chain is thought to be the interaction between cell membranes that regulate puberty. Undifferentiated primate ES cells, human EC and ES cells express SSEA - 3 and ssea-4, but do not express ssea-1. The undifferentiated mouse ES cells express SSEA -1, but do not express ssea-3 or SSEA - 4. A marker for hematopoietic stem cells? CD34 (salivary proteins on the cells surface) : CD34 has been the focus of interest since the discovery of a small number of bone marrow cells. Most of the activity was found in the cells of the CD34 positive rich set from bone marrow and peripheral blood. CD34 is thought to be a marker for hematopoietic stem cells (HSCs). CD34, which has been shown to decline after protocells have been differentiated into mature cells, als