害程度及调脂措 施有效性的指标明.pdfVIP

2007 2 22 2 ∃ 121∃ : 1005- 2224( 2007) 02- 0121- 03 胡 鹏, 经承学, 覃远汉, 裴 娟, 李铭芳 探讨原发性肾病综合征患儿 ( PNS) 血脂代谢紊乱 肾功能改变的关系 200401! 200601,根据肾功能检查结果, 将广西医科大学第 一附属医院儿科收治的 76例 PNS患儿分成无肾功能损害组 ( 46例) 肾功能损害组( 30例 ), 检测血浆总胆固醇 ( C) 甘油三酯( G) 高密度脂蛋白(HDL)非高密度脂蛋 白 ( nonHDL)低密度脂蛋白( LDL) 载脂蛋白 A1(ApoA 1)载脂蛋白 B(ApoB) ApoA 1/B血浆尿素氮 ( BUN ) 肌酐清除率 (Ccr)和尿酸(UA)等指标 ( 1)肾功能损害组 GBUNCcr和 UA 均明显高于无肾功能损害 组; ( 2) 76例 PNS患儿 G Ccr及UA呈高度正相关 ( P 001), ApoA1 Ccr呈中度正相关( P 005), ApoB UA呈中度正相关( P 005) ; ( 3) 76例 PNS患儿 nonHDL LDL呈高度正相关( P 001) PNS合 并肾功能损害的血脂代谢紊乱以 G显著增高为特征; G 和 nonHDL变化可以作为临床判断 PNS患儿肾功能损 害程度及调脂措施有效性的指标 肾病综合征; 高脂血症;肾功能; 儿童 : R72 : A N eph rotoxicity induced by dyslip id em ia in ch ild ren w ith prim ary neph rit ic syndrom e. H U Peng, JIN G Cheng xue, QIN Yuanhan, et a.l Departm ent of Pediatrics, he F irstAff iliatedH osp ital of GuangxiM edical University, Nanning 530021, China A bstrac t O bjective o probe into the relationsh ip bewt een dyslipidem ia and the alternation of renal function in chil dren w ith prmi ary nephritic syndrom e( PNS). M ethods otally 76 ch ildren w ith PNS w ere divided into tw o groups, the nonrenal inadequacy group( 46 ch ildren) and the renal inadequacy group(30 children), accord ing to renal function. otal cholesterol( C), triglyceride( G), high density lipoprotein(HDL), nonHDL, low density lipoprotein(LDL), apolipopro tein A1(ApoA 1), apolipoprotein B (ApoB), ApoA 1/B, blood urea nitrogen( BUN ), creatinine clearance rate(Ccr) and u ric acid(UA ) in plasma w ere detected. R esu lts ( 1) G, BUN, Ccr and UA in the renal inadequacy group significantly increased com paredw ith the nonrenal inadequacy group. ( 2) here wa