天麻素对体外模拟脑缺血损伤大鼠脑微血管内皮细胞的保护作用_胡京红.pdfVIP

·124 · () 2007 22 2 · · ＊ 胡京红　司银楚　洪庆涛　黄翔　唐一鹏　青雪梅　李澎涛 (, 100029) 　　::(BMEC), BMEC 。:BMEC, , 、 (NO)。:BMEC ; BMEC 、 NO ;BMEC (P0.05);BMEC NO (P0.05)。: BMEC , (EC);EC NO 。 BMEC 。 :;;;;(MTT );(NO) Protective Effects of Gastrodine on Cultivated Rat Brain Microvessel Endothelial Cells by Mimic Cerebral Ischemia Hu Jinghong 　i Yinchu　Hong Qingtao 　Huang Xiang 　Tang Yipeng 　Qing Xuemei 　Li Pengtao (Preclinical Medicine College, Beijing University of Tradition Chinese Medicine, Beijing 100029) Objective:To observe the protective effects of Gastrodine on the cultivated rat brain microvessel endothe- 　　Abstract: lial cells damage by mimic cerebral ischemia.Methods:The endothelial cells activity, survival rate, the change in NO con- tent, and the effects of Gastrodine were observed in the cultivated rat brain microvessel endothelial cells (BMEC)damaged by mimic cerebral ischemia.Results:The activity and survival rate of BMEC in the ischemia groups are obviously lower than that in the normal groups;comparedwith the normal groups, the activity, survival rate and NO content of BMEC in the Gas- trodin groups have the increasing tendency;comparing to the ischemia groups, the activity of BMEC in the Gastrodin groups obviously increasing (P0.05);NO content of ischemia injured BMEC in the high dose Gastrodin groups increases obvi- ously (P0.05).Conclusion:The Gastrodin at suitable does could enhance the activity of ischemia injured BMEC and in- crease survival rate of injured EC and NO secretary volume of EC.It suggests that the gastrodin plays the protection role in ischemia injured rat BMEC