pulmonarysarcomatoidcarcinoma.PDFVIP

临床与病理杂志 2017, 37(3) 600 J Clin Pathol Res doi: 10.3978/j.issn.2095-6959.2017.03.027 View this article at: /10.3978/j.issn.2095-6959.2017.03.027 58例肺肉瘤样癌的临床特征与预后因素 黄韵坚1，钟礼花2，陈芳芳2，陈燕坪2，黄章洲1，卢建平2，王晓江2，师怡2，林贤东2，庄武1， 许春伟2，陈刚2 (福建医科大学附属福建省肿瘤医院 1. 胸部肿瘤内科；2. 病理科，福州 350014) [摘　要] 目的：探讨肺肉瘤样癌(pulmonary sarcomatoid carcinoma，PSC)的临床特征与预后因素。方法：回 顾性分析58例PSC，分别对临床特征、免疫组织化学、基因状态进行分析，Kaplan-Meier法计算 生存率，Log-rank法进行生存率显著性检验，COX风险比例回归模型进行单因素和多因素分析。 结果：58例PSC，以男性、65岁和吸烟的患者为主，应用COX风险比例回归模型分析对PSC的性 别、年龄、吸烟史、EGFR基因突变状态、ALK融合基因状态、分期和组织亚型进行分析，结果显 示ALK融合基因状态和组织亚型是PSC独立的预后因素(P0.05)。结论：PSC的诊断主要依靠形态 和免疫组织化学，影响其预后的因素主要为ALK融合基因状态和组织亚型。 [关键词] 肺肉瘤样癌；EGFR基因；ALK基因；突变率；预后 Clinical features and prognostic factors of 58 cases of pulmonary sarcomatoid carcinoma HUANG Yunjian1, ZHONG Lihua2, CHEN Fangfang2, CHEN Yanping2, HUANG Zhangzhou1, LU Jianping2, WANG Xiaojiang2, SHI Yi2, LIN Xiandong2, ZHUANG Wu1, XU Chunwei2, CHEN Gang2 (1. Department of Medical Thoracic Oncology; 2. Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China) Abstract Objective: To investigate the characteristics of pulmonary sarcomatoid carcinoma (PSC) and analyze the prognostic factors. Methods: Fifty-eight patients with PSC were retrospectively reviewed on the clinical data, immunohistochemistry and genetic state, and the survival rate was calculated by Kaplan-Meier method and log- rank test was used to compare the survival rates. Univariate and multivariate factors for surv