针刺治疗脓毒症机理研究进展 吴凡伟,周仙仕,叶烨.pdfVIP

·1046·?????????????????????????????国际中医中药杂志2016年11月第38卷第11期 Int J Trad Chin Med, Nevember 2016, Vol. 38, No.11? ·综述· 针刺治疗脓毒症机理研究进展 吴凡伟 周仙仕 叶烨 【摘要】 本文从循证医学角度归纳了近年来针刺治疗脓毒症的基础与临床文献，具体分为针刺疗 法对脓毒症炎症反应、免疫反应调节作用及对重要脏器(胃肠道、肺脏、肝脏、心脏等)的保护作用，可 为认识、研究及运用针刺治疗脓毒症提供参考。 【关键词】 脓毒症；针刺疗法；炎症反应；免疫调节；脏器保护；机制；综述 Research progress on the mechanism of acupuncture therapy on treating the sepsis Wu Fanwei*, Zhou Xianshi, Ye Ye. *Department of Traditional Chinese Medicine, Songgang Peoples Hospital in Baoan District, Shenzhen 518105,China Corresponding author: Zhou Xianshi, Department of Emergency of Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou 510120, China; Email:163.com 【Abstract】 Acupuncture has showed an amazing clinical effect on the sepsis, but its functional mechanism has not been unreported. Thus, this article reviewed the pre-clinical and clinical evidence of acupuncture therapy in treating the sepsis of recent years. This paper included two parts: acupuncture regulating the disorders of inflammatory reaction and immunoreaction, and protecting the vital organs (such as gastrointestinal tract, the lung, the liver and the heart). This paper can help to provide basic for the researches and clinical application of acupuncture therapy in treating the sepsis. 【 Key words 】 Sepsis; Acupuncture therapy; Inflammatory reaction; Immunoregulation; Organ protection; Mechanism; Review 脓毒症是急危重症领域的顽疾之一，全世界每年数百 脓毒症的必备要素。2000 年 Borovikova 等[2]提出刺激副交 万人因此死亡，致死率约 25%，且发病率逐年增加[1]，治 感神经可减轻内毒素介导的全身炎性介质大量释放造成 疗费用高昂，给社会带来沉重的经济、医疗负担。炎症反 的全身炎症反应损伤，但未发现抗炎通路的特定抗炎靶点 应、免疫失衡是脓毒症重要的发病机制，抑制炎症反应及 及具体抑炎机制。2002