生物制药专业英语presentation生物制药专业英语presentation.pptVIP

In 1990 the recombinant（重组） expression vector of the exogenous gene （外源基因） was injected into the skeletal muscle（骨骼肌） of mice by Wolff, as a result, the recombinant expression vector of the gene was detected in one part of the muscle cells, and expression product of the gene induced immune response to produce the antibody.;; Immune mechanisms of DNA vaccine;DNA vaccine invades the organism;引自百度百科; The preparation of DNA vaccine;Selection of the objective gene;Select the appropriate carrier;Expression vector of construction; the Immunization of DNA vaccine; Injection of immune pathway;Particle bombardment（基因枪法）;Skin and mucosal immunity; The advantages and disadvantages of DNA vaccine;The advantages of DNA vaccine;Although the DNA vaccine is the product of artificial design（人工设计）, but there are some problems to be solved. As a kind of gene regulation means, DNA vaccine must carry foreign genes, after exogenous gene into the body, There exists the possibility of activation of host endogenous（内源性） oncogenes （原癌基因） or inactivation of tumor suppressor genes（抑癌基因） in host.; The application status of DNA vaccine;At present, the Food and Drug Administration(FDA) has approved the Ebola virus（埃博拉病毒）, malaria（疟疾）, AIDS and cancer and other DNA vaccines in clinical observation and has been formally approved or conditionally approved for clinical use of vaccine are 3 types: Masini Lo virus DNA vaccine（马西尼罗病毒DNA 疫苗）, salmon infectious hemorrhagic necrosis virus DNA vaccine（ 鲑鱼传染性出血坏死病毒DNA 疫苗） and the dog melanoma DNA vaccine（狗黑素瘤DNA 疫苗）.;Thank you!