Histone_deacetylase抑制剂_激动剂_MCE.pdfVIP

www.MedChemE 1 HDAC Histone deacetylase Histone deacetylases are a class of enzymes that remove acetyl groups (O=C-CH3) from an epsilon;-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. Type: HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10, HDAC11 etc.. The deacetylation of histones is associated with transcriptional silencing. Imbalance of histone acetylation is a common aspect of many disorders. Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptic. HDIs are studied as a treatment for neurodegenerative diseases and have a potential for cancer therapy. Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg Purity: 98.02% Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg Purity: 98.64% Clinical Data: Phase 1 , Phase 1 Size: 5 mg, 10 mg, 50 mg Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg Purity: 98.88% Clinical Data: Phase 1, Phase 2 Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg Purity: 98% Clinical Data: Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg HDAC Inhibitors Modulators Bioactivity: 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs. Bioactivity: 4SC-202 free base is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs. Bioactivity: Rocilinostat (ACY-1