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Heart rate and arterial pressure variability in the experimental renovascular hypertension model.pdf

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Heart rate and arterial pressure variability in the experimental renovascular hypertension model

Clinical 139 (2008) 38–45 /locate/autneuAutonomic Neuroscience: Basic andHeart rate and arterial pressure variability in the experimental renovascular hypertension model in rats Hugo C.D. Souza a,?, Marli C. Martins-Pinge b, Valdo J. Dias da Silva c, Audrey Borghi-Silva d, Ada C. Gastaldi a, Jo?o Henrique D. Blanco a, Geisa C.S.V. Tezini a a Department of Biomechanics, Medicine and Rehabilitation, School of Medicine of Ribeir?o Preto, University of S?o Paulo, Brazil b Department of Physiological Sciences of the University of Londrina, Brazil c Department of Biological Sciences, Federal University of Triangulo Mineiro, Uberaba, Brazil d Department of Physiotherapy of the Federal University of S?o Carlos, S?o Carlos, Brazil Received 24 August 2007; received in revised form 16 December 2007; accepted 5 January 2008Abstract This studywas conducted in one kidney, one clip (1K1C)Goldblatt hypertensive rats to evaluate vascular and cardiac autonomic control using different approaches: 1) evaluation of the autonomicmodulation of heart rate (HR) and systolic arterial pressure (SAP) bymeans of autoregressive power spectral analysis 2) assessment of the cardiac baroreflex sensitivity; and 3) double blockade with methylatropine and propranolol. The 1K1C group developed hypertension and tachycardia. The 1K1C group also presented reduction in variance as well as in LF (0.23±0.1 vs. 1.32±0.2 ms2) and HF (6.6±0.49 vs. 15.1±0.61 ms2) oscillations of pulse interval. Autoregressive spectral analysis of SAP showed that 1K1C rats had an increase in variance and LF band (13.3±2.7 vs. 7.4±1.01 mmHg2) in comparison with the sham group. The baroreflex gain was attenuated in the hypertensive 1K1C (?1.83±0.05 bpm/mmHg) rats in comparison with normotensive sham (?3.23±0.06 bpm/mmHg) rats. The autonomic blockade caused an increase in the intrinsic HR and sympathetic predominance on the basal HR of 1K1C rats. Overall, these data indicate that the tachycardia observed in the 1K1C group may be att