An-overview-of-values-for-the-threshold-of-toxicological-concern_2012_Toxicology-Letters.pdf

MA E E a A R R A A K T T E R C d a C E C J ( E A C C t a 0 hToxicology Letters 211 (2012) 296– 303 Contents lists available at SciVerse ScienceDirect Toxicology Letters jou rn al h om epa ge: www.elsev ier .com/ locate / tox le t ini review n overview of values for the threshold of toxicological concern .C. Hennes ? uropean Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Av. E. Van Nieuwenhuyse 4, B-1160 Brussels, Belgium r t i c l e i n f o rticle history: eceived 26 October 2011 eceived in revised form 19 March 2012 ccepted 21 March 2012 a b s t r a c t An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is struc- tured by use/exposure scenario and provides, in particular, key information on the underlying databases.vailable online 30 March 2012 eywords: hreshold of toxicological concern oxicological endpoint xposure route It is aimed to support the application of the TTC approach in the risk assessment of chemicals whereby it is important to be aware under which circumstances a certain TTC value can be applied. Some recom- mendations for potential future developments to further improve the TTC approach are also being made. ? 2012 Elsevier Ireland Ltd. All rights reserved. isk assessment ontents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297 2. Regulatory application . . . . . . .