tDCS with extracephalic electrode.pdfVIP

RESEARCH ARTICLE Open Access Effect of tDCS with an extracephalic reference electrode on cardio-respiratory and autonomic functions Yves Vandermeeren1,2*, Jacques Jamart3, Michel Ossemann1,2 Abstract Background: Transcranial direct current stimulation (tDCS) is used in human physiological studies and for therapeutic trials in patients with abnormalities of cortical excitability. Its safety profile places tDCS in the pole- position for translating in real-world therapeutic application. However, an episode of transient respiratory depression in a subject receiving tDCS with an extracephalic electrode led to the suggestion that such an electrode montage could modulate the brainstem autonomic centres. We investigated whether tDCS applied over the midline frontal cortex in 30 healthy volunteers (sham n = 10, cath- odal n = 10, anodal n = 10) with an extracephalic reference electrode would modulate brainstem activity as reflected by the monitoring and stringent analysis of vital parameters: heart rate (variability), respiratory rate, blood pressure and sympatho-vagal balance. We reasoned that this study could lead to two opposite but equally interesting outcomes: 1) If tDCS with an extra- cephalic electrode modulated vital parameters, it could be used as a new tool to explore the autonomic nervous system and, even, to modulate its activity for therapeutic purposes. 2) On the opposite, if applying tDCS with an extracephalic electrode had no effect, it could thus be used safely in healthy human subjects. This outcome would significantly impact the field of non-invasive brain stimulation with tDCS. Indeed, on the one hand, using an extra- cephalic electrode as a genuine neutral reference (as opposed to the classical “bi-cephalic” tDCS montages which deliver bi-polar stimulation of the brain) would help to comfort the conclusions of several modern studies regard- ing the spatial location and polarity of tDCS. On the other hand, using an extracephalic reference electrode may i