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Discovery and Characterization of Potent and Selective Inhibitors against the.pdf

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Discovery and Characterization of Potent and Selective Inhibitors against the

UNIVERSITY OF CALIFORNIA, IRVINE Discovery and Characterization of Potent and Selective Inhibitors against the PEA-hydrolyzing enzyme, N-acylethanolamine-hydrolyzing Acid Amidase DISSERTATION submitted in partial satisfaction of the requirements for the degree of DOCTOR OF PHILOSOPHY in Pharmacology and Toxicology by Carlos Efrain Solorzano Say Dissertation Committee: Professor Daniele Piomelli, Chair Professor Paolo Sassone-Corsi Professor Robert Edwards Professor George Chandy, Oversight Member 2010 PR EV IE W UMI Number: 3404654 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. UMI 3404654 Copyright 2010 by ProQuest LLC. All rights reserved. This edition of the work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, MI 48106-1346 PR EV IE W Chapter 3 ? 2009 Carlos E. Solorzano, PNAS All other materials ? 2010 Carlos E. Solorzano PR EV IE W ii DEDICATIO To my wife, Elizabeth, To my parents, Carlos and Ruth Solorzano, To my brother Jose Solorzano, To my parents-in-law, Sergio and Elizabeth Montalvo, To my Family and Friends, And to my Lord and Savior, Jesus Christ. PR EV IE W iii TABLE OF CO TE TS Page LIST OF FIGURES v LIST OF TABLES vii ACKNOWLEDGEMENTS v