Hypoxic-Ischemic Encephalopathy in Preterm Infants.pdfVIP

下载本文档

7
0
约3.97万字
约 8页
2017-04-09 发布于江苏
举报
版权申诉

Hypoxic-Ischemic Encephalopathy in Preterm Infants.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Hypoxic-Ischemic Encephalopathy in Preterm Infants

Hypoxic-Ischemic Encephalopathy in Preterm Infants: Antecedent Factors, Brain Imaging, and Outcome PAVITHRA LOGITHARAJAH, MARY A. RUTHERFORD, AND FRANCES M. COWAN Division of Clinical Sciences [P.L., M.A.R., F.M.C.], Imperial College London and MRC Clinical Sciences Centre, London W12 0HS, United Kingdom; Division of Neonatology [P.L., F.M.C.], Imperial College Comprehensive Biomedical Research Centre, London W12 0HS, United Kingdom ABSTRACT: Our objectives were to establish antecedent factors and patterns of brain injury and their prognostic value in preterm infants with hypoxic-ischemic encephalopathy (HIE). Essential in- clusion criteria were gestation (GA) 36 wk, Apgar scores 5/7 at 1/5 min, major resuscitation at birth, and a brain MRI 6 postnatal wk. At least one additional criterion was required of the following: abnormal intrapartum CTG, sentinel event, meconium, cord pH 7.0, neonatal seizures, and multiorgan failure. Antenatal and peri- natal data and 2 y neurodevelopmental outcome were documented. Fifty-five infants (GA 26–366; median, 35 wk) were eligible; all had 1–6 (median, 3) additional criteria. Placental abruption was the commonest identifiable antecedent event. Evidence of infection was not prominent. Main sites of injury were basal ganglia (BG, 75%), mostly severe, white matter (WM, 89%), mostly mild, brainstem (44%), and cortex (58%). Brainstem injury was associated with severe BG, WM, and cortical injury. Two-year outcome: death (32%), cerebral palsy (26%, mostly severe quadriplegia), mild im- pairment (10%), and normal (32%). Significant central gray matter and brainstem injury was found in many preterm infants with HIE. Neonatal MRI findings allowed accurate prediction of neurodevel- opmental outcome. Early MRI is feasible and a valuable tool in this poorly reported group of infants. (Pediatr Res 66: 222–229, 2009) Hypoxic-ischemic encephalopathy (HIE), and subsequentmorbidity and mortality, is seldom reported in preterm infants. Criter