调节性B细胞在变应性疾病中对T细胞免疫的调节作用及其调.PDFVIP

临床与病理杂志 J Cl in Path ol R e s 2015, 35(6) 1137 调节性B细胞在变应性疾病中对T细胞免疫的调节作用及其调节 因素 王萌 综述 曹志伟 审校 (中国医科大学附属盛京医院耳鼻咽喉科，沈阳 110004 ) [摘　要] 由于B细胞(Breg cells)在免疫反应中具有介导特异性免疫反应、分泌抗体的作用，一直以来人们都 认为B细胞在免疫反应中起到正性的免疫调节作用。然而，越来越多的研究证实B细胞同样具有负 性的免疫调节作用。在变应性疾病中，某种具有调节功能的B细胞亚集可以通过分泌IL -10、TGF-I 等细胞因子方式促进调节性T细胞(Treg cells)的分化或是直接抑制免疫性T细胞的增殖。这种B细胞 的亚集被称作调节性B细胞，即B调细胞。同时，B调细胞所处的微环境对B调细胞的产生、增殖及 分泌也起到调节作用。在这篇综述中，我们结合近年来的研究成果，讨论B调细胞在变应性疾病 中，对T细胞免疫反应进行调节的可能机制以及B调细胞所处微环境中的某些因素对B调细胞的调 节作用，并展望了B调细胞未来的研究方向。 [关键词] Breg细胞；IL -10；T细胞；Treg细胞 Regulatory function on T cell immunity of regulatory B cell and its regulating factors in allergic diseases WANG Meng, CAO Zhiwei (Otorhinolaryngological Department, Shengjing Hospital of China Medical University, Shenyang 110004, China) Abstract As B cells (Breg cells) can mediate specific immune responses and secrete antibodies in the immune response, it has long been believed that B cells play a positive regulatory role in the immune response. However, more and more studies have confirmed that B cells also have negative immunoregulatory effects. In allergic diseases, a B cell subset has regulatory function by means of secreting cytokines (IL-10, TGF-B, ect.) to promote differentiation of regulatory T cells (Treg cells) or directly inhibit the proliferation of T cells. This subset of B cells is called regulatory B cells. Meanwhile, the microenvironment also plays a regulatory role in differentiation and proliferation and secretion of Breg cells. In this review, we combine many research achievements in recent years, to discuss the possible regulatory mechanism of Breg cells on T cell immunity in allergic disease, and some regulatory factors in the microenvironment of Breg cells, and the research direction in the future of Breg cells. Keywords Breg cells; IL-10; T cells; Treg cells 收稿日期 (Date of reception)：2015–04–09 通信作者 (Corresponding author)：曹志伟，Email: caozw@ 基金项目 (Foundation item)：国家自然基金青年科学基金项目 。is work was supported by e You