高三化学中国国家集训队上课课件3_Metathesis.pptVIP

Organo-transition Metal Chemistry Olefin Metathesis Representative Catalysts Developments in Catalyst Categories of Metathesis Events Engineering the Direction of the Equilibrium for Ring Closing Metathesis Factors Affecting RCM Substitution Effects on RCM:A Comparison of Catalysts RCM: An Invaluable Tool for Generation of Cyclic Structures in TOS ROM/Double RCM 1 ROM/Double RCM or RCM ROM/RCM 2 ROM/Double RCM 3 RCM: Macrocycle Synthesis En Masse Generation of Macrocycles Using Conformational Analysis En Masse Generation of Macrocycles Using Conformational Analysis Cross Metathesis 1 Cross Metathesis 2 Enyne Metathesis Tandem Dienyne RCM 2 Enyne-CM/RCM/DA Macro-Enyne-RCM 1  Type II Diene Formation Macro-Enyne-RCM 2 Transannular Diels-Alder Reaction Diyne Metathesis Diyne Macro-RCM RCM-Heck Reaction Tandem Heck-RCM Combination of Enyne-RCM with Intermolecular Diels-Alder Reaction Shair. M. D. et al, unpublished 更多资源 Alkyne RCM in combination with Lindlar partial hydrogenation is a selective way to generate macrocyclic (Z)-olefins Catalyst (Schrock alkylidyne complex) Furstner. A. et al J. Am. Chem. Soc. 1999, 121. 11108 Lecture: Transition Metal Catalyzed Complexity Generating Reactions 2Metathesis Outline Overview of olefin metathesis Olefin metathesis Ring closing metathesis Ring opening metathesis Cross metathesis Enyne metathesis Diyne metathesis Reference ACIEE., 2000, 39, 3012 ACIEE., 1997, 36, 2036 JCS. PT1, 1998, 371 Tetrahedron. 1998, 54, 4413 Acc. Chem. Res. 1995, 28, 446 更多资源 Chemistry involves intermediates containing transition metal- carbon bonds Olefin Metathesis: metal-catalyzed exchange of olefins. Metal-carbene Complex Olefin metathesis catalysts tend to be between Schrock and Fischer carbenes Development of well-defined metal-carbene complexes as pre-catalysts Sigma-donating N-heterocyclic carbene ligands increase general reactivity and thermal stability Arduengo A. et al Acc. Chem. Res. 1999, 32, 913 Attaching Privileged chiral lig