A PROLONGED RELEASE PARENTERAL DRUG DELIVERY SYSTEM.pdfVIP

Volume 3, Issue 1, July – August 2010; Article 001 ISSN 0976 – 044X International Journal of Pharmaceutical Sciences Review and Research Page 1 Available online at A PROLONGED RELEASE PARENTERAL DRUG DELIVERY SYSTEM – AN OVERVIEW Hitesh Bari Bharati vidyapeeth college of pharmacy, morewadi, near chitranagari, kolhapur-416013 Email: barihitesh99@ ABSTRACT The Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for. It requires frequent injection, which ultimately leads to patient discomfort. For this reason, drug delivery system which can reduce total number of injection throughout the effective treatment, improve patient compliance as well as pharmacoeconomic. These biodegradable injectable drug delivery system offer attractive opportunities for protein delivery and could possibly extend patent life of protein drugs. This article explores various prolonged release parenteral drug delivery system and their strategies of preparation, their potential benefits/drawbacks and in-vitro testing methods. Keywords: In situ forming implant, Microspheres, Liposomes, Suspension, Solid lipid nanoparticle, In-vitro testing devices INTRODUCTION As in the case of mucosal and transdermal drug delivery, where systemic bioavailability of a drug is always limited by its permeability across a permeation barrier (epithelial membrane or stratum corneum)1 and oral drug delivery in which the systemic bioavailability of a