2013Modern Pathology-The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine.pdfVIP

下载本文档

5
0
约 11页
2017-04-05 发布于江苏
举报
版权申诉

2013Modern Pathology-The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

2013Modern Pathology-The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine

The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine Peng Qi1,2 and Xiang Du1,2 1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China and 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China The conventional view of gene regulation in biology has centered around protein-coding genes via the central dogma of DNA-mRNA-protein. The discovery of thousands of long non-coding RNAs (lncRNAs) has certainly changed our view of the complexity of mammalian genomes and transcriptomes, as well as many other aspects of biology including transcriptional and posttranscriptional regulation of gene expression. Accumulating reports of misregulated lncRNA expression across numerous cancer types suggest that aberrant lncRNA expression may be a major contributor to tumorigenesis. Here, we summarize recent data about the biological characteristics of lncRNAs in cancer pathways. These include examples with a wide range of molecular mechanisms involved in gene regulation. We also consider the medical implications, and discuss how lncRNAs can be used for cancer diagnosis and prognosis, and serve as potential therapeutic targets. As more examples of regulation by lncRNA are uncovered, one might predict that the large transcripts will eventually rival small RNAs and proteins in their versatility as regulators of genetic information. Modern Pathology (2013) 26, 155–165; doi:10.1038/modpathol.2012.160; published online 21 September 2012 Keywords: cancer; diagnostics; gene expression; long non-coding RNAs The central dogma of gene expression is that DNA is transcribed into mRNA, which in turn serves as the template for protein synthesis. Intensive investiga- tions over the last few decades have focused on the role of protein-coding genes in the pathogenesis of cancer. However, recent advances in technologies, such as tiling arrays and RNA deep sequencing (RNA-seq), have made it possible to survey the transcriptome