弥漫性细支气炎管.pptVIP

Diffuse panbronchiolitis 胡建敏 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. In 1969, the disease was named DPB to distinguish it from chronic bronchitis Diffuse refers to the distribution of the lesions throughout both lungs pan- refers to the involvement of inflammation in all layers of the respiratory bronchioles Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. EPIDEMIOLOGY East Asians, predominantly in Japan usually occurring in the 20-40 yrs 11 cases per 100,000 people no remarkable sex predominance could be observed Two-thirds of patients are nonsmokers and patients have no particular history of inhalation of toxic fumes Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. associated with sinusitis in 75% of patients etiology is not clear Asian immigrants also suffers. research has shown an association with HLABw54, found predominantly among East Asians Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. At autopsy, lungs in DPB appear hyperinflated and often show bronchiectasis Cut sections show yellow nodules, 2–3 mm in diameter, centring on small airways Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. PATHOLOGY transmural and peribronchial infiltration at the level of the respiratory bronchioles by lymphoctyes,plasma cells and histocytes accumulation of interstitial foam cells lymphoid hyperplasia most of the alveoli are unaffected ectasia of proximal membranous bronchioles,intraluminal inflammatory exsudates ultimately, widespread bronchiectasis occur Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Cl