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Herpetol ameliorates allergic contact dermatitis through regulating T-lymphocytes.pdf
International Immunopharmacology 40 (2016) 131–138
Contents lists available at ScienceDirect
International Immunopharmacology
journal homepage: /locate/intimp
Herpetol ameliorates allergic contact dermatitis through regulating T-lymphocytes
Xiang Li a,1, Xingqi Wang a,b,1, Hezhong Jiang a,c,1, Guohui Zhang a, Rui Tan c, Yang Sun a, Xuefeng Wu a,
Renxiang Tan a,?, Qiang Xu a,?
a State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China b Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou, China c School of Life Science and Engineering, and College of Medicine, Southwest Jiaotong University, Chengdu, China
article info
Article history: Received 27 April 2016 Received in revised form 23 August 2016 Accepted 23 August 2016 Available online 31 August 2016
Keywords: Herpetol Allergic contact dermatitis T-lymphocytes Glycolysis Drug candidate
abstract
An immunosuppressant with fewer adverse effects is still urgently needed for increasing numbers of patients suffering from allergic contact dermatitis. In the present study, we aimed to investigate the immunosuppressive activity of herpetol on T-lymphocytes in vitro and in vivo and explore its potential pharmacological mechanism. The results showed that herpetol could effectively inhibit the proliferation of activated T cells and reduce the production of pro-in?ammatory cytokines at 5–20 μM. Additionally, the ear swelling and in?ammatory responses induced by picryl chloride were signi?cantly ameliorated by herpetol at 20–40 mg/kg. Moreover, herpetol could cause cell cycle arrest of activated T cells in a dose-dependent manner. Furthermore, herpetol reduced the expression and activity of HIF-1α, Glut1 and LDHA, leading to glycolysis inhibition in activated T cells. Taken together, herpetol showed an immunosuppressive activity against T-cell mediated immune responses in vitro and in vivo, and
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