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Functional hydrogel contact lens for drug delivery in the application of oculopathy therapy.pdf

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Functional hydrogel contact lens for drug delivery in the application of oculopathy therapy.pdf

journal of the mechanical behavior of biomedical materials 64 (2016) 43–52 Available online at /locate/jmbbm Research Paper Functional hydrogel contact lens for drug delivery in the application of oculopathy therapy Xiaohong Hua,n, Huaping Tanb, Lingyun Haoa,n aSchool of Material Engineering, Jinling Institute of Technology, Nanjing, 211169 China bBiomaterials for Organogenesis Laboratory, School of Materials Science Engineering, Nanjing University of Science Technology, Nanjing, 210094 China article info Article history: Received 9 April 2016 Received in revised form 1 July 2016 Accepted 5 July 2016 Available online 12 July 2016 Keywords: Hydrogel β-cyclodextrin (β-CD) Drug delivery Functional contact lens Oculopathy therapy abstract Although hydrogel contact lens has attracted increasingly concerns as delivery carriers in the ?eld of oculopathy therapy, traditional hydrogel does not show excellent drug encapsulated and controlled properties due to simple hydrophilic polymer chain lacking extra interaction with drug molecule. Herein, functional hydrogels were synthesized in this research to delivery ophthalmic drug for oculopathy therapy. Functional monomer of mono-GMA-β-CD and functional crosslinker of MA-β-CD were incorporated into hydrogel by copolymerization. For hydrogels, equilibrium swelling ratio and contact angle was in?uenced by mono-GMA-β-CD ratio and MA-β-CD ratio, respectively. All hydrogels exhibited similar water loss behavior and good transparency. Hydrogels had rheological characteristic of typical elastomer. Viscoelasticity and surface morphology of hydrogel were also affected by mono-GMA-β-CD ratio and MA-β-CD ratio. In the aspect of properties, functional hydrogel containing β-CD domain exhibited better protein resistance capacity and signi?cantly higher equilibrium encapsulated drug amount than traditional hydrogel. Besides the performance, drug release behavior of drug encapsulated hydrogel was adjusted by both mono-GMA-β-CD ratio and MA-β-