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3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profileview ordering Feasibility of right ventricular myocardial damage assessment using a swine animal model.pdf

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3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profileview ordering Feasibility of right ventricular myocardial damage assessment using a swine animal model.pdf

Magnetic Resonance Imaging 39 (2017) 7–14 Contents lists available at ScienceDirect Magnetic Resonance Imaging journal homepage: Original contribution 3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS pro?le/view ordering: Feasibility of right ventricular myocardial damage assessment using a swine animal model Keigo Kawaji a,?, Akiko Tanaka b, Mita B. Patel a, Hui Wang d, Francesco Maffessanti a, Takeyoshi Ota b, Amit R. Patel a,c a Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States b Department of Surgery, Section of Cardiothoracic Surgery, The University of Chicago, Chicago, IL, United States c Department of Radiology, The University of Chicago, Chicago, IL, United States d Philips, Gainesville, FL, United States. article info Article history: Received 1 November 2016 Received in revised form 27 December 2016 Accepted 23 January 2017 Available online xxxx Keywords: Myocardial infarction Late gadolinium enhancement MRI Viability imaging Navigator Breath-hold abstract Aims: To develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV). Methods and results: A k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed. 8 pigs were surgically prepared with cardiac patch implantation in the RV, followed in 60 days by 1.5 T MRI. LGE with Phase-Sensitive Inversion Recovery (PSIR) were performed as follows: 1) 2DBH using pneumatic control, and 2) navigator-gated, 3D free-breathing (3DFB)-CP-LGE with slice-tracking. The animal heart was excised immediately after cardiac MR for scar volume quanti?cation. RV scar volumes were also delineated from the 2DBH and 3D