甲磺酸培氟沙星车间工艺设计书技术分析.docx

题目年产260吨甲磺酸培氟沙星车间精制成盐工段工艺设计学生姓名：陈静学号：110150094班级：化工与制药1103所在院(系): 化工与材料工程学院指导教师: 周莉莉完成日期: 2015年3月4日年产260吨甲磺酸培氟沙星车间甲化段工艺设计摘要本设计是年产260吨甲磺酸培氟沙星甲基化甲基化车间工艺设计。甲基化工段是以诺氟沙星作为起始原物料，甲醛、甲酸、乙醇、氨水和活性炭作为辅料，生成培氟沙星。本设计确定生产260吨甲磺酸培氟沙星的生产工艺流程；完成本工段的全部工艺计算（物料衡算，热量衡算），根据衡算结果选取适当的生产设备尺寸型号；绘制带控制点的工艺流程图、生产车间平面布置图、生产车间立面布置图和甲基化反应釜装配图。本设计方案操作简单、原料廉价易得、能耗低、对环境的污染也较小、且“三废”易处理，是目前国内生产甲磺酸培氟沙星最成熟的合成路线。关键字：甲磺酸培氟沙星甲基化；诺氟沙星；工艺设计THE SALT SEGMENT TECHNOLOGICAL DESIGN FOR ANNUAL OUTPUT OF 260 TONS MESYLATE PEFLOXACINABSTRACTThis work is about to salt segment process design of an annual 400 tons pefloxacin mesylate. The process use methyl salt as starting raw materials, methane sulfuric acid, ethanol, and activated carbon as accessories, generating mefloquine crude. The production of 350 tons designed to determine pefloxacin mesylate production process; complete this section in full process calculation (material balance, heat balance), according to the accounting results, the appropriate equipment size models was selected; layout, technology flow diagram and the methylation reactor assembly drawing were carried out. The design is simple, cheap raw materials, low energy consumption less environmental pollution, and the three wastes easy to handle, is the current domestic production of pefloxacin mesylate most sophisticated synthetic routes.Keywords:pefloxacin mesylate;salt reaction; mefloquine; technological design目 录课程设计任务1前言21 产品概述21.1产品名称、化学结构、理化性质21.1.1产品名称31.1.2化学结构和分子量31.1.3理化性质31.2临床用途41.3固体原料的密度、熔点42 产品工艺简介42.1本设计采用的工艺路线42.1.1甲基化42.1.2中和42.1.3成盐42.1.4精制52.1.5 工艺路线53 工艺设计依据63.1设计任务依据63.2工艺路线的的主要依据63.3质量标准73.4 包装规格要求及贮藏83.4.1 成品的包装规格83.4.2贮藏83.5 原辅料、包装材料质量标准及规格84 物料衡算94.1 计算方法与原则94.1.1 物料衡算的目的94.1.2 物料衡算的依据94.1.3 物料衡算基准94.1.4 甲磺酸培氟沙星收率与所用原料物性工艺参数104.2 物料平衡总线114.2.1正批生产114.2.2回收生产12 4.3精制工段的物料衡算134.3.1脱色134.3.2压滤144.3.3冷冻结晶154.3.4离心甩料154.4甲基回收工段的物料衡算164.4.1精母液中和回收釜的物料衡算165 能量衡算175.1 各物质物化参数的查取与计算175.1.1 原料比热的计算与查取175.1.2液体原料比热的计算与查取185.1.3部分原料燃烧热的计算和查取195.2精制工段能量衡算205.2.1精制反应阶段235.2.2精制重结晶阶