201601107-吲哚菁绿在乳腺癌前哨淋巴结活检中应用23要求修改.doc

吲哚菁绿在乳腺癌前哨淋巴结活检中应用 indocyanine green，ICG）在乳腺癌前哨淋巴结活检(sentinel lymph node biopsy,SLNB)中应用价值。方法：选取我院 2013年1月至2015年12月的160例乳腺癌患者进行检测分析，随机分为亚甲蓝组、亚甲蓝+吲哚菁绿联合组分别为65例和95例。比较2组患者的检出成功率、准确率和假阴性率。结果：亚甲蓝+吲哚菁绿联合组的检出成功率和准确性明显高于亚甲蓝组，具有统计学意义（P＜0.05）；亚甲蓝+吲哚菁绿联合组的假阴性率明显低于亚甲蓝组组，具有统计学意义（P＜0.05）。亚甲蓝+吲哚菁绿联合组检出的前哨淋巴结（2.9±0.9）枚/例明显多于亚甲蓝组组（1.9±0.5）枚/例，具有统计学意义（P＜0.05）。结论：乳腺癌前哨淋巴结进行吲哚菁绿检测降低假阴性率提供可靠的依据，提高乳腺癌的诊断水平。 关键词：吲哚菁绿；乳腺癌；前哨淋巴结 Application of indocyanine green in sentinel lymph node biopsy in breast cancer Abstract Objective: To explore the application value of indocyanine green in sentinel lymph node biopsy in breast cancer. Methods: selected in our hospital in 2013 January to December 2015 160 cases of breast cancer patients were detected and analyzed were randomly divided into sub methylene blue group, methylene blue and indocyanine green in the combination group were 65 cases and 95 cases. The detection success rate, accuracy and false negative rate of the 2 groups were compared. Results: methylene blue + indocyanine green in the combined group detection success rate and accuracy was significantly higher than that in the group of methylene blue, with statistical significance (P 0.05); methylene blue + indocyanine green joint group of the false negative rate was significantly lower than that of methylene blue group, with significant difference (P 0.05). Methylene blue + indocyanine green joint detection of sentinel lymph node (2.9 + 0.9) gold / cases was significantly higher than that of the methylene blue group (+ 1.9 0.5) pieces / cases, with statistical significance (P 0.05). Conclusion: breast cancer sentinel lymph node indocyanine green test to reduce the false negative rate and provide a reliable basis to improve the diagnostic level of breast cancer. Keywords: Indocyanine green; breast cancer; sentinel lymph node 腋窝前哨淋巴结（sentinel lymph node，SLN）作为乳腺癌转移的第一站，在肿瘤转移时常首先受累，而腋窝SLN有无肿瘤转移理论上可以预测腋窝淋巴结转移的状况[1]。近些年，吲哚菁绿已逐渐被应用于乳腺癌前哨淋巴结活检中。本研究于2013年1月至2015年12月对160例乳腺癌患者前哨淋巴