血糖波动和精细调控xin__培训课件.pptVIP

* ANA 038 Summary: Blood glucose concentration was significantly lower after breakfast and dinner, before lunch and at bedtime in the BIAsp? 30 group. Analysis of 8-point blood glucose profiles revealed significantly lower blood glucose concentrations after breakfast and dinner, before lunch and at bedtime in the BIAsp? 30 group. At 12 weeks, values were approximately 1% lower in the BIAsp? 30 group after breakfast and dinner (10.4 versus 11.4 mmol/l in BIAsp? 30 and BHI 30 groups respectively after breakfast, and 9.22 versus 10.2 mmol/l after dinner; p 0.05 between groups for breakfast and p 0.02 for dinner). Before lunch, blood glucose concentrations of 6.64 mmol/l in the BIAsp? 30 group compared favourably with 7.57 mmol/l in the BHI 30 group (p 0.02), while at bedtime, concentrations of 8.22 versus 9.10 mmol/l in the BIAsp? 30 and BHI 30 groups, respectively, again favoured BIAsp? 30 (p 0.05). At other time points, between-treatment differences did not reach statistical significance. Importantly, mean prandial glucose concentration was significantly lower in the BIAsp? 30 group after 12 weeks (1.66 versus 2.34 mmol/l in BIAsp? 30 and BHI 30 groups, respectively; p 0.02). 同样的，上面所说的一天两次注射即早餐前和晚餐前的注射，餐后血糖升高幅度用诺和锐30要比人胰岛素30R要低。此外还有一个重要发现，在夜间两点的时候，诺和锐30并不是很低，因此它可以避免夜间严重的低血糖。 * ANA 038 Summary: Subjects in the BIAsp? 30 group experienced nearly half as many major hypoglycaemic episodes as those in the BHI 30 group, as well as a trend towards reduced nocturnal hypoglycaemia. Based on actual exposure, analysis of hypoglycaemic episodes was based on 138 patients in the BIAsp? 30 group and 153 in the BHI 30 group. This is explained by a pharmacy dispensing error, where two patients who were randomised to receive BIAsp? 30 actually received BHI 30: therefore, these two patients were moved to the BHI 30 group. 8% of patients in the BIAsp? 30 group reported a total of 20 major hypoglycaemic episodes, whereas 12% of the BHI 30 group reported 42 major events. The