Sorbiol abstract.docVIP

Sorbitol abstract Scand J Gastroenterol.?2011 Jul;46(7-8):837-43. doi: 10.31092011.575175. Epub 2011 Apr 19. Follow-up of coeliac disease with the novel one-hour 13C-sorbitol?breath test versus the H2-sorbitol?breath test. Tveito K,?Hetta AK,?Askedal M,?Brunborg C,?Sandvik L,?L?berg EM,?Skar V. Source Department of Medicine, Lovisenberg Diakonale Hospital, Oslo, Norway. kari.tveito@oslo-universitetssykehus.no Abstract BACKGROUND: We recently developed a (13)C-sorbitol?breath test ((13)C-SBT) as an alternative to the H(2)-sorbitol?breath test (H(2)-SBT) for coeliac disease. In this study we compared the diagnostic properties of the H(2)-SBT and the (13)C-SBT in follow-up of coeliac disease. MATERIAL AND METHODS: Twenty-seven coeliac patients on a gluten-free diet (GFD) performed the breath tests. All had been tested before treatment in the initial study of the (13)C-SBT, in which 39 untreated coeliac patients, 40 patient controls, and 26 healthy volunteers participated. Five gram?sorbitol?and 100 mg (13)C-sorbitol?were dissolved in 250 ml tap water and given orally. H(2), CH(4) and (13)CO(2) were measured in end-expiratory breath samples every 30 min for 4 h. Increased H(2) concentration ≥20 ppm from basal values was used as cut-off for the H(2)-SBT. Sixty minutes values were used as diagnostic index in the (13)C-SBT. RESULTS: (13)CO(2) levels at 60 min increased in 20/26 treated coeliac patients (77%) after GFD, but were significantly lower than in control groups. Out of 20 patients who had a positive H(2)-SBT before GFD, 12 had a negative H(2)-SBT after GFD. Peak H(2) concentrations were not correlated with (13)C-SBT results. CONCLUSION: The study confirms the sensitivity of a one-hour (13)C-SBT for small intestinal?malabsorption. The (13)C-SBT has superior diagnostic properties compared with the H(2)-SBT in follow-up of coeliac disease. Curr Gastroenterol Rep.?2009 Oct;11(5):368-74. Fructose-sorbitol?malabsorption. Fernández-Ba?ares F,?Esteve M,?Viver