Rh2 are asociated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte.docVIP

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Rh2 are asociated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte.doc

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Rh2 are asociated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte

Available online at Biochemical and Biophysical Research Communications 364 (2007) 1002–1008 /locate/ybbrc Anti-obesity e?ects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte Jin-Taek Hwanga,1, Soon-Hee Kima,1, Myoung-Su Leea, Sung Hee Kima, Hye-Jeong Yanga, Min-Jung Kimb, Hak-Soo Kimb, Joohun Hab, Myung Sunny Kima, Dae Young Kwona,* a Functional Food Research Center, Korea Food Research Institute, 516 Baekhyun, Bundang-gu, Songnam-si, Gyungki-do 463-746, Republic of Korea b Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species, Kyung Hee University School of Medicine, Seoul 130-701, Republic of Korea Received 9 October 2007 Available online 29 October 2007 Abstract Metabolic disorders such as obesity are major obstacles in improving the average life span. Therefore, a therapeutic approach using natural compounds has been proposed as a novel strategy for preventing metabolic disorders. Ginsenoside Rh2 is one of the ginsenosides that exert anti-diabetes, anti-in?ammatory, and anti-cancer e?ects. However, the anti-obesity e?ects of Ginsenoside Rh2 remain unclear. Here, we investigated the anti-obesity ability of ginsenoside Rh2 using cell culture systems. Ginsenoside Rh2 e?ectively inhibited adipo- cyte di?erentiation via PPAR-c inhibition. Next, to ?nd speci?c target molecules based on this result, we used cell culture systems to examine whether AMPK activation was involved in the anti-obesity ability of ginsenoside Rh2 since several published papers have indi- cated that AMPK signaling is involved in the regulation of metabolic disorders. Ginsenoside Rh2 signi?cantly activated AMPK in 3T3- L1 adipocytes. In addition, we also examined the e?ect of AMPK on lipolysis molecules such as CPT-1 and UCP-2 by using an AMPK inhibitor. Ginsenoside Rh2 e?ectively induced CPT-1 and UCP-2 and this induction was abolished by AMPK inhibitor