太极通天液对偏头痛病人血浆内皮素水平影响.docVIP

太极通天液对偏头痛病人血浆内皮素水平影响.txt32因为爱心，流浪的人们才能重返家园；因为爱心，疲惫的灵魂才能活力如初。渴望爱心，如同星光渴望彼此辉映；渴望爱心，如同世纪之歌渴望永远被唱下去。 太极通天液对偏头痛病人血浆内皮素水平影响 更新日期：2011-03-07 点击： 项建平　接贵涛　公伟宏　薛彦忠 提要　目的：探讨太极通天液对偏头痛病人血浆内皮素(ET)的影响。方法：采用放射免疫法对110例偏头痛病人口服太极通天液和安慰剂治疗前后血浆ET进行测定，并观察其近期疗效。观察期为4周。结果：太极通天液可明显降低偏头痛病人血浆ET水平( P＜0.01)，其近期疗效优于安慰剂( P＜0.01)。结论：太极通天液能降低偏头痛病人血浆ET水平，是防治偏头痛的良药。 关键词　太极通天液；　偏头痛；　内皮素；　治疗 Effects on Plasma Endothelin Level in Treating Migraine with Taiji Tongtian Oral Solution Xiang Jianping, Jie Guitao, Gong Weihong, et al Yishui Central Hospital, Shandong Province 276400 Abstract　Objective:To study the effects on plasma endothelin (ET) in treating migraine with Taiji Tongtian oral solution. Method: The ET level in plasma was measured by radioimmunoassay in 110 migraine patients treated with Taiji Tongtian oral solution and placebo. The efficacy of therapy in the near future was observed simultaneously. The duration was 4 weeks. The efficacy was assessed on the basis of the changes of plasma ET and the curative effect in the near future. Results:The results showed that the curative effect of Taiji Tongtian oral solution in the near future was superior to placebo and the difference was statistic and significant(P＜0.01). Taiji Tongtian oral solution could decrease the plasma ET level in migraine patients significantly(P＜0.01). Conclusions:It suggests that Taiji Tongtian oral solution could decrease the plasma ET level in migraine patients, it is a good drug in the prophylaxis of migraine. Key words　Taiji Tongtian oral solution;　Migraine;　Endothelin;　Treatment 　　太极通天液是四川太极集团生产的中成药方剂，具有活血化瘀、疏风止痛、活络通脉的功能，广泛用于防治各类头痛。近年来研究表明：内皮素(ET)是迄今为止体内最强的血管收缩物质［1］，偏头痛病人血浆、脑脊液中ET含量较正常明显增高［2，3］。说明血浆ET水平的升高和持续异常共同构成了偏头痛的病理生理基础［4］。为进一步探讨太极通天液治疗偏头痛的作用机理，1996～1998年我们对110例头痛病人应用太极通天液和安慰剂治疗进行双盲对照研究，观察其对血浆ET水平的影响，并同时观察其近期疗效。 1　对象与方法 1.1　研究对象：全部病例均来自我院神经内科门诊。 1.1.1　入选标准：偏头痛的诊断根据国际头痛协会1988年制定的诊断标准［5］，神经系统检查阴性，头颅CT/MRI正常。所选病例均为头痛发作期，病程在1 a以上，且在入选前1月未服用其它防治偏头痛药物。 1.1.2　排除标准：凡有内科疾病、高血压及明显精神心理因素者均不作为选择对象。