新药设计与合成全英文汇报.ppt

Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action （一）Background （二）Content （三）Discussion and Conclusion Outline The sturcture of influenza viruses Influenza is a majorin fectious disease of humans and animals causing significant morbidity and mortality worldwide. Background Ref: J. Proteome Res. 2011, 10, 3450–3459. Background Influenza viruses are typed into three categories (A, B, C). According to differences in viral matrix (M) proteins and nucleoproteins. Influenza A, responsible for most flurelated deaths, is further subtyped according to the antigenic characteristics of the hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins. Ref: Analyical chemistry, 2006, 11(1):7910-7915. On the Types of influenza viruses influenza A viruses (IAV) While type B influenza is almost exclusively a human pathogen, type A influenza also infects birds and other mammals. Background Curcumin Curcumin is a colouring compound present in the rhizome of Curcuma longa. It shows many pharmacological properties including antioxid anti-inflammatory and some other activities. Recently, curcumin has been proven to exert anti-influenza activity by inhibition of the virus-cell attachment. Ref：Bioorg Med Chem. 2012,12:5046-5052. Content Resveratrol (RV) RV is a very interesting polyphenol belonging to the stilbene family.A few years ago, we showed that RV inhibits influenza virus replication in vitro and in vivo. Surprisingly, these effects are not related to its well-known antioxidant activity. Ref：Bioorg Med Chem. 2012,12:5046-5052. Content The polyphenol compounds Content Inhibit late phases of influenza viruslife-cycle These data indicate that the antiviral activity of the compounds is largely related to their inhibition of virus life-cycle steps occurring 2-8 h, and possibly related to post-transcriptional events. Content Compound 4 inhibits expression of late viral proteins These res