待发文章丹莪妇康煎膏治疗痛经的meta分析讲解.docVIP

丹莪妇康煎膏治疗痛经的荟萃分析 于坤，陈明*，肖政，魏巍，王正龙 （遵义医学院第一附属医院，贵州 遵义563099） 【摘要】 目的：采用荟萃分析法评价丹莪妇康煎膏治疗痛经的疗效及安全性。方法：计算机检索Cochrane图书馆临床对照试验资料库、MEDLINE(1966-2013.5)、EMbase（1984-2013.5）、CBM（1978-2013.5）、维普（建库-2013.5）、万方（建库-2013.5）、CNKI（建库-2013.5）等数据库，手工检索并向药厂索要相关资料，最大范围收集全世界关于丹莪妇康煎膏治疗痛经的随机对照试验结果，按照Cochrane协作网提供的方法进行荟萃分析。结果：（1）共纳入10篇中文文献，包括983例患者，其中治疗组530例，对照组453例；（2）两组治愈率比较：I2=65%，P＜0.1采用随机效应模型，合并效应量OR=1.69，95%CI[1.01，2.81]，P＜0.05，差异有统计学意义；治疗组的治愈率高于对照组。（3）两组总有效率比较：I2=0%，P＞0.1，采用固定效应模型，合并效应量OR=1.24，95%CI[0.81，1.90]，p＞0.05，差异无统计学意义；（4）两组治疗前痛经症状积分比较：I2=0%，P＞0.1，采用固定效应模型，MD=0.2，95%CI[-0.11,0.50]，P＞0.05，差异无统计学意义；（5）两组治疗后痛经症状积分比较：I2=96%，P＜0.1，采用随机效应模型，MD=-0.94 95%CI[-2.11，0.23]，P＞0.05，差异无统计学意义；（6）治疗组治疗前、后痛经症状积分比较：I2=86%,P＜0.1，采用随机效应模型，MD=5.79，95%CI[5.01，6.56]，P＜0.05，差异有统计学意义；（7)对照组治疗前、后痛经症状积分比较：I2=91%，P＜0.1，采用随机效应模型MD=4.62，95%CI[3.71，5.53]，P＜0.05，差异有统计学意义。结论：丹莪妇康煎膏治疗痛经与其他药物相比更能提高治愈率，且治疗后可减轻痛经程度，但是在总有效率方面与其他药物相比无明显优势。采用其他药物治疗后也能缓解痛经程度，在这方面丹莪妇康煎膏也无优势。 【关键词】 丹莪妇康煎膏；痛经；meta分析；系统评价 Dan’efukang soft extract for Dysmenorrhea:Meta-analysis YuKun,ChengMing, Xiao Zheng,WeiWei,WangZhengLong The first affiliated hospital of zunyi medical college, zunyi,guizhou,563099 [Abstract]objective To assess the efficacy and safety of dan’efukang soft extract for dysmenorrhea by meta-analysis. Methods Cochrane Controlled trials register,Medline,EMBASE, VIP，Wanfang，CNKI and other datebase were searched.Besides some relevant information was also hunted by manual search from pharmaceutical companies to collect randomized controlled trials results about Dan’efukang soft extract for Dysmenorrhea in the world. Meta-analysis according to the method provided by the Cochrane Collaboration was used for the pooling of the results. Results (1) 10 Chinese literature were selected, including 983 cases of patients, the treatment group 530 cases, 453 cases of the control group.(2) There were statistically significant differences in recovery rate between two groups; I2 = 65%, P0.1, used the random effects model, merge effect quantit