依达拉奉对小鼠网膜下腔出血早期erk12调控海马神经元调亡及vegf介导脑动脉内皮细胞凋亡的影响.pdf

I ，t∥ 0000………24 附图附表…………………………………………………00 讨论································································“”一“”一”27 小结·············································……·“”一”“一”一一””…·29 参考文献………………………………………………………………29 第二部分 神经元凋亡及依达拉奉的治疗作用 前言…·······························································”一··”””32 刖舌…一一一”一“”一“一一“”一”“”““一””””””””一””””””””。jZ 材料与方法……………………………………………………………33 结果····-···-…····················…····一·····”··················“一··”一”42 附图附表………………………………………………………………46 讨论·································“····一··························”···”一”55 小结··················································-············…····……”58 参考文献………………………………………………………………58 第三部分 小鼠蛛网膜下腔出血早期血管痉挛与VEGF介导的脑动脉内 皮细胞凋亡的关系及依达拉奉的治疗作用 前言”一”“一““一”“一””一””””．．一““．．””一““一”“一””一”一一”0—2刖舌”一”“”““一”“一””一””””””“““””““““”“一””一”“一” 材料与方法……………………………………………………………62 结果············…························…································．．”70 附图附表………………………………………………………………73 讨论··············································································78 OQOOOD 小结··················IbQIb OIIbl···-··············…···························79 参考文献……………………………………………………………79 结论·····················-························································82 综述蛛网膜下腔出血早期脑损伤的实验研究进展……………………83 致谢··············································································104 个人简历…………………………………………………………………105 中文摘要 依达拉奉对小鼠蛛网膜下腔出血早期ERKl／2调控海马神经元 凋亡及VEGF介导脑动脉内皮细胞凋亡的影响 摘 要 第一部分 小鼠蛛网膜下腔出血模型制备及评价 目的： 制作小鼠血管内插线致蛛网膜下腔出血模型，并对该模型的 死亡率、神经学改变及蛛网膜下腔出血的程度进行评价。 方法： 组6只、模型组24只。 2模型制备采用血管内插线法建立小鼠蛛网膜下腔出血模型。手